Haemostatic changes associated with fluid resuscitation in canine parvoviral enteritis

Journal of the South African Veterinary Association


 
 
Field Value
 
Title Haemostatic changes associated with fluid resuscitation in canine parvoviral enteritis
 
Creator Whitehead, Zandri Goddard, Amelia Botha, Willem J. Pazzi, Paolo
 
Subject Veterinary Science Parvoviral enteritis; haemostasis; thromboelastography; veterinary science; fluid resuscitation
Description The haemostatic status of dogs with canine parvovirus (CPV) enteritis, within 24 h of admission after initial fluid administration, has been described previously, but the haemostatic status at admission and after standard fluid resuscitation, as well as after initial fluid redistribution, has not been investigated previously. The objective of this study was to characterise the haemostatic status at admission and describe the effect of crystalloid fluid resuscitation on haemostatic variables in dogs with CPV enteritis. Twenty-seven client-owned, hospitalised dogs with confirmed natural CPV infection and 15 healthy age-matched controls were included in a prospective, observational clinical study. The volume of resuscitation fluid, haematocrit (HCT), platelet count, thromboelastography (TEG) variables, antithrombin (AT) activity, fibrinogen- and C-reactive protein (CRP) concentrations were measured in all dogs at admission, after fluid resuscitation and, in 10 dogs, after receiving an additional 3 hours of maintenance-rate crystalloid fluids. For the CPV group at admission, the median TEG reaction time (R) and maximum amplitude (MA) or clot strength, as well as the median HCT, fibrinogen and CRP concentrations, were significantly increased compared to the controls. After fluid resuscitation, median R was significantly shorter, MA significantly increased and HCT and AT activity significantly decreased compared to admission values. The haemostatic variables remained unchanged after 3 h of maintenance-rate crystalloid therapy. The increased clot strength present in dogs with CPV enteritis at admission was exacerbated after fluid resuscitation and persisted for hours after large-volume crystalloid fluid administration.
 
Publisher AOSIS
 
Contributor Health and Welfare Sector Education and Training Authority (HWSETA).
Date 2020-07-29
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Prospective, observational clinical study
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/jsava.v91i0.2005
 
Source Journal of the South African Veterinary Association; Vol 91 (2020); 9 pages 2224-9435 1019-9128
 
Language eng
 
Relation https://jsava.co.za/index.php/jsava/article/view/2005/2602 https://jsava.co.za/index.php/jsava/article/view/2005/2601 https://jsava.co.za/index.php/jsava/article/view/2005/2603 https://jsava.co.za/index.php/jsava/article/view/2005/2600
 
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Rights Copyright (c) 2020 Zandri Whitehead, Amelia Goddard, Willem J. Botha, Paolo Pazzi https://creativecommons.org/licenses/by/4.0