Paediatric antiretroviral overdose: A case report from a resource-poor area
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Paediatric antiretroviral overdose: A case report from a resource-poor area | |
| Creator | Ogoti, Bryan A. Otedo, Angela A. Chokwe, Thomas M. | |
| Description | Introduction: Toxic side effects from antiretroviral overdose in children have not been widely reported. Antiretroviral drugs are widely used as oral medications throughout sub-Saharan Africa.Patient presentation: We describe the clinical presentation and management of a 3-year-old male in rural Kenya, who accidentally overdosed on abacavir/lamivudine combination pills. The number of pills taken was approximately 250 tablets, that is 15 g of abacavir and 7.5 g of lamivudine. He presented 24 hours later to Homabay County Referral Hospital, with unresponsiveness, inability to feed and absence of playfulness. Physical examination revealed a sick-looking, ‘unconscious’ child, responding only to voice, with tachycardia, hypertension and moderate dehydration.Management and outcome: He was managed conservatively with rehydration, namely intravenous 1125 mL of 5% dextrose in 0.9% saline, and the monitoring of his neurologic status, urine output and all vital signs. He regained normal neurological function after 24 hours, and recovered uneventfully, but was lost to follow-up.Conclusion: In an area endemic for HIV and where antiretroviral drug use is commonplace, there is a need for health education to ensure that parents keep drugs out of the reach of children. In the case of a suspected overdose, parents need to be reminded to seek medical attention immediately. Physician awareness of the clinical presentation, management and challenges with an antiretroviral drug overdose is also important. | |
| Publisher | AOSIS | |
| Date | 2020-07-21 | |
| Identifier | 10.4102/sajhivmed.v21i1.1094 | |
| Source | Southern African Journal of HIV Medicine; Vol 21, No 1 (2020); 3 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/1094/1921
https://sajhivmed.org.za/index.php/hivmed/article/view/1094/1920
https://sajhivmed.org.za/index.php/hivmed/article/view/1094/1922
https://sajhivmed.org.za/index.php/hivmed/article/view/1094/1919
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