Anti-diarrhoeal activity of aqueous extract of Cochlospermum planchonii (Hook Fx. Planch) leaves in female Wistar rats

Journal of Medicinal Plants for Economic Development

Field Value
Title Anti-diarrhoeal activity of aqueous extract of Cochlospermum planchonii (Hook Fx. Planch) leaves in female Wistar rats
Creator Yakubu, Musa T. Amoniyan, Omowunmi D. Mohammed, Mariam O. Assin, Christine I. Abubakar, Jemilat O. Salimon, Saoban S. Omar, Sikemi A.
Subject Biochemistry anti-diarrhoea; castor oil; Cochlospermum planchonii; Cochlospermacea; acetylcholine esterase
Description Background: The folkloric use of Cochlospermum planchonii is yet to be substantiated with scientific evidence.Aim: The aqueous extract of C. planchonii leaves was evaluated for anti-diarrhoeal activity at 125, 250 and 500 mg/kg body weight in female Wistar rats.Setting: This research is a phytopharmacological investigation.Methods: Animal were monitored for indicators of diarrhoea in the 3 models after treatments.Results: An aqueous extract of C. planchonii leaves contained 10 secondary metabolites, with alkaloids (16.05 mg/L) occurring the most, whilst quinones (0.7 mg/L) were the least. The extract significantly (p 0.05) prolonged the onset time of diarrhoea, decreased water content, fresh weight and total number of wet faeces in a dose-dependent manner, and increased the percentage inhibition of defecation. The extract produced dose-specific changes on intestinal superoxide dismutase, glucose and reduced glutathione whereas the levels of intestinal Na+/K+-ATPase, alkaline phosphatase, catalase, nitric oxide were significantly (p 0.05) increased in the castor oil-induced diarrhoeal model. The masses and volumes of intestinal fluid decreased significantly (p 0.05) whereas the inhibition of intestinal fluid content increased like those of atropine-treated diarrhoeal rats in the enteropooling model. The extract dose-dependently decreased the distance travelled by the charcoal meal and increased the intestinal nitric oxide and acetylcholinesterase in the charcoal meal transit model.Conclusion: The aqueous extract of C. planchonii leaves exhibited anti-diarrhoeal activity via anti-motility and anti-secretory means. The flavonoids, alkaloids, tannins, phenolics and saponins might have acted to enhance the activities of Na+/K+-ATPase, antioxidant enzymes, intestinal glucose levels and the neurotransmitters.
Publisher AOSIS Publishing
Date 2020-06-30
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/jomped.v4i1.81
Source Journal of Medicinal Plants for Economic Development; Vol 4, No 1 (2020); 8 pages 2616-4809 2519-559X
Language eng
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Coverage Nigeria — —
Rights Copyright (c) 2020 Musa T. Yakubu, Omowunmi D. Amoniyan, Mariam O. Mohammed, Christine I. Assin, Jemilat O. Abubakar, Saoban S. Salimon, Sikemi A. Omar