Adult T-cell leukaemia/lymphoma in an adolescent patient: Expect the unexpected

SA Journal of Oncology

Field Value
Title Adult T-cell leukaemia/lymphoma in an adolescent patient: Expect the unexpected
Creator Abdullah, Ibtisam Nell, Erica-Mari Chapanduka, Zivanai C.
Subject — ATLL; HTLV-1; T-cell lymphoproliferative neoplasm; flower cells; adolescent
Description This case study explores a clinicopathological presentation of Adult T-cell leukaemia/lymphoma (ATLL) at Tygerberg Hospital; a disease associated with adulthood noted in an adolescent patient. Adult T-cell leukaemia–lymphoma oncogenesis develops through a multistep process with an accumulation of mutations. Infection through human T-lymphotropic virus type 1 (HTLV-1) is the first step of a multistep process resulting in eventual clonal proliferation of mature T-cells. There is a long latency period of 20–50 years from the time of infection with HTLV-1 to the development of symptoms of ATLL; thus, ATLL is a malignancy associated with adulthood. The median age of diagnosis is 58, ranging from the third to ninth decade of life. This is an ideal learning case as it highlights the importance of recognising ATLL in children and young adults in our population.
Publisher AOSIS
Date 2020-05-25
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v4i0.121
Source South African Journal of Oncology; Vol 4 (2020); 4 pages 2523-0646 2518-8704
Language eng
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Rights Copyright (c) 2020 Ibtisam Abdullah, Erica-Mari Nell, Zivanai C. Chapanduka