An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa

SA Journal of Oncology

Field Value
Title An 8-year retrospective study of adult and paediatric Burkitt’s lymphoma at Tygerberg Hospital, South Africa
Creator Musekwa, Ernest Chapanduka, Zivanai C. Bassa, Fatima Kruger, Mariana
Subject paediatric oncology; haematology epidemiology; Burkitt lymphoma; human immunodeficiency virus; tuberculosis; children; adults; treatment; outcome; South Africa
Description Background: Burkitt lymphoma(BL) is a high grade non-Hodgkin lymphoma, which may be underdiagnosed in South Africa, due to a high burden of infectious diseases such as HIV and TB which may present with similar clinical features.Aim: To describe demographics and clinico-pathological characteristics of patients diagnosed with BL.Setting: Tygerberg Hospital (TBH), South Africa between 2007-2014.Methods: We performed a retrospective descriptive and survival analysis of patients diagnosed with BL at TBH between 01 January 2007 and 31 December 2014 with at least 24-month follow-up. Data was collected from the Tygerberg Lymphoma Study Group database and the South African Children Cancer Study Group Tumour Registry.Results: There were 73 patients with BL, of whom 68 were admitted to TBH and whose data was further analysed. The majority of patients were adults (74%). There was a female predominance in adults and a male predominance in children (p = 0.002). Various regimens were used in adults while a single treatment protocol was used in children. The proportion of patients with HIV and advanced BL was higher in adults than in children. The 2-year overall survival of the treatment group was 45%. The outcome of patients with BL in adults (34%) was poorer than that of children (69%) (p = 0.022). HIV negative patients had a non-significant survival advantage (57%) over HIV positive patients with 41% 2-year overall survival (p = 0.2876).Conclusion: This study demonstrates a better cure rate in children treated for BL compared to adults, with HIV-infection being a risk factor for poor outcome.
Publisher AOSIS
Date 2020-04-30
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective Analysis
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v4i0.93
Source South African Journal of Oncology; Vol 4 (2020); 8 pages 2523-0646 2518-8704
Language eng
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Coverage South Africa 2007 - 2014 2 - 69 years; males (29) and females (39); African, Caucasian, mixed race, Indian., however not taken into account due to the retrospective nature of the study; work/job not included in the study, as the study involved children
Rights Copyright (c) 2020 Ernest Musekwa, Zivanai C. Chapanduka, Fatima Bassa, Mariana Kruger