Metastatic screening for patients with newly diagnosed breast cancer: Who and how?

SA Journal of Oncology

Field Value
Title Metastatic screening for patients with newly diagnosed breast cancer: Who and how?
Creator Edge, Jenny Budge, Melissa Webner, Adiel Doruyter, Alexander Cilliers, Glen Malherbe, Francois
Subject metastatic; screening; review breast cancer; metastatic disease; screening; guidelines; best practice; review
Description Background: Staging for breast cancer patients, as defined by the American Joint Committee on Cancer (AJCC), has historically been limited to anatomical staging. However, the eighth version of the AJCC guidelines has been altered to include tumour biology. Anatomical staging still has a place especially in low-middle income countries where the majority of patients present with locally advanced or metastatic disease.Aim: This review article considers which newly diagnosed breast cancer patients should be referred for anatomical staging and the pros and cons of the different modalities available in South Africa.Method: The different modalities available were reviewed with respect to metastatic screening for asymptomatic women. The usefulness of the modalities were considered with reference to organ-specific disease rather than the stage of the patient.Results: Any person with newly diagnosed breast cancer and symptoms suggestive of systemic involvement should be investigated. All symptomatic women who present with a tumour larger than 5 cm, radiological or clinical evidence of nodal disease, triple negative or HER2+ve tumours should have metastatic screening. This gives information about the primary as well as the metastatic status.Conclusion: However, increasingly, the major determinant of treatment is the biology of the cancer and not the anatomical stage. In future, this trend is likely to increase with anatomical staging becoming less important.
Publisher AOSIS
Date 2020-04-06
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — review
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v4i0.94
Source South African Journal of Oncology; Vol 4 (2020); 6 pages 2523-0646 2518-8704
Language eng
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Coverage South Africa N/A patients with newly diagnosed breast cancer
Rights Copyright (c) 2020 Jenny Edge, Melissa Budge, Adiel Webner, Alexander Doruyter, Glen Cilliers, Francois Malherbe