Failure of diplodiatoxin to induce diplodiosis in juvenile goats
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Failure of diplodiatoxin to induce diplodiosis in juvenile goats | |
| Creator | Botha, Christo J. Ackerman, Louis G.J. Masango, Mxolisi G. Arnot, Luke F. | |
| Description | Diplodiosis is an important neuromycotoxicosis of ruminants in South Africa when grazing on harvested maize fields in winter. It is believed to be caused by mycotoxin(s) synthesised by Stenocarpella (Diplodia) maydis. Although several metabolites have been isolated from S. maydis culture material, none of these have been administered to ruminants to reproduce the disease. The objectives of this study were to isolate diplodiatoxin and to administer it to juvenile goats. Diplodiatoxin, considered as a major metabolite, was purified from S. maydis-infected maize cultures (Coligny 2007 isolate). Following intravenous administration of 2 mg and 4 mg diplodiatoxin/kg body weight for five consecutive days to two juvenile goats, no clinical signs reminiscent of diplodiosis were observed. Based on previous experimental results and if diplodiatoxin was the causative compound, the dosage regimen employed was seemingly appropriate to induce diplodiosis. In addition, intraruminal administration of 2 mg/kg diplodiatoxin to one goat for three consecutive days also did not induce clinical signs. It appears as if diplodiatoxin alone is not the causative compound. Other metabolites and/or mixtures of diplodiatoxin and other mycotoxins, when available in sufficient quantities, should also be evaluated. | |
| Publisher | AOSIS | |
| Date | 2020-03-05 | |
| Identifier | 10.4102/ojvr.v87i1.1712 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 87, No 1 (2020); 4 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/1712/2075
https://ojvr.org/index.php/ojvr/article/view/1712/2074
https://ojvr.org/index.php/ojvr/article/view/1712/2076
https://ojvr.org/index.php/ojvr/article/view/1712/2064
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