Diffuse large B-cell lymphoma in a high human immunodeficiency virus (HIV) prevalence, low-resource setting

SA Journal of Oncology

Field Value
Title Diffuse large B-cell lymphoma in a high human immunodeficiency virus (HIV) prevalence, low-resource setting
Creator Magangane, Pumza S. Mohamed, Zainab Naidoo, Richard
Subject Oncology; Anatomical Pathology DLBCL; HIV infection; South Africa; oncology; treatment
Description Background: Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous disease that includes a wide spectrum of lymphomas posing challenges in diagnosis and treatment. Diffuse large B-cell lymphoma is the most common lymphoma subtype occurring in older populations as well as in younger HIV-infected patients. Outcomes have improved with antiretroviral therapy and the use of rituximab; however, it remains poorly treated in resource-constrained countries.Aim: This study aimed to determine differences in clinical features between HIV-negative and HIV-positive DLBCL cases by conducting a retrospective studySetting: A tertiary hospital in Cape Town, South Africa.Methods: We evaluated 263 DLBCL cases grouped according to HIV status over an 11-year period.Results: The clinical features for HIV-negative and HIV-positive DLBCL cases were similar except for age of presentation and frequency of elevated lactate dehydrogenase (LDH). Several factors were prognostic for all DLBCL cases, including age of presentation, gender, stage, LDH and bone marrow involvement. In addition, extranodal site was also a prognostic indicator for the HIV-negative cohort.Conclusion: Our study concluded that HIV-negative and HIV-positive DLBCL cases generally have similar clinicopathological and prognostic features.
Publisher AOSIS
Date 2020-02-24
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Retrospective review
Format text/html application/epub+zip text/xml application/pdf
Identifier 10.4102/sajo.v4i0.104
Source South African Journal of Oncology; Vol 4 (2020); 7 pages 2523-0646 2518-8704
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajo.org.za/index.php/sajo/article/view/104/315 https://sajo.org.za/index.php/sajo/article/view/104/314 https://sajo.org.za/index.php/sajo/article/view/104/316 https://sajo.org.za/index.php/sajo/article/view/104/313
Coverage Cape Town; Western Cape; South Africa 2003-2013 DLBCL; HIV; Response to treatment
Rights Copyright (c) 2020 Pumza S. Magangane, Zainab Mohamed, Richard Naidoo https://creativecommons.org/licenses/by/4.0