Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa
South African Journal of Psychiatry
| Field | Value | |
| Title | Accelerated theta-burst repetitive transcranial magnetic stimulation for depression in South Africa | |
| Creator | Bröcker, Erine van den Heuvel, Leigh Seedat, Soraya | |
| Description | This case series documents local experience using accelerated theta-burst repetitive transcranial magnetic stimulation (rTMS) as a supplementary treatment for depression in both major depressive disorder (MDD) and bipolar disorder (BD). Nine consenting patients (MDD = 7; BD = 2) each received 20 accelerated theta-burst sessions over 8 days. Improvement was monitored using the Centre for Epidemiological Studies Depression (CES-D) Scale and the Clinical Global Impression (CGI) Scale at baseline, at day 5 and at day 8 of rTMS treatment. We performed a Wilcoxon matched-pairs signed-rank test to determine whether there was a difference in scores from baseline to post-treatment. The CES-D scores decreased significantly from baseline to post-treatment (Z = −2.547, p = 0.011) with five patients experiencing at least a 50% symptom reduction on the CES-D. CGI severity scores also decreased significantly between baseline and post-treatment (Z = −2.547, p = 0.011). The most commonly reported adverse effect was mild headaches, lasting a few hours during and after rTMS treatment. The findings suggest that the accelerated theta-burst rTMS protocol for depression is well tolerated with most patients also experiencing symptomatic improvement by day 8. | |
| Publisher | AOSIS | |
| Date | 2019-11-27 | |
| Identifier | 10.4102/sajpsychiatry.v25i0.1346 | |
| Source | South African Journal of Psychiatry; Vol 25 (2019); 4 pages 2078-6786 1608-9685 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajp.org.za/index.php/sajp/article/view/1346/1584
https://sajp.org.za/index.php/sajp/article/view/1346/1583
https://sajp.org.za/index.php/sajp/article/view/1346/1585
https://sajp.org.za/index.php/sajp/article/view/1346/1582
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