First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria)
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | First study of hepatitis delta virus in Algeria: Seroprevalence and risk factors in Setif region (east of Algeria) | |
| Creator | Gasmi, Abdelkader Guenifi, Wahiba Ouyahia, Amel Rais, Mounira Boukhrissa, Houda Hachani, Abderahmen Mechakra, Salah Laouamri, Slimen Touabti, Abderezak Lacheheb, Abdelmadjid | |
| Description | Background: No recent data are available on hepatitis delta virus (HDV) prevalence in Algeria. For this reason we conducted an epidemiological study, cross-sectional seroprevalence of HDV in the region of Setif.Methods: Between 2011 and 2014, sera samples of 500 patients (carrying HBsAg) admitted to the Division of Infectious Diseases Teaching Hospital, Setif (east of Algeria), were tested for anti-HDV-IgG ab (ETI-AB-DeltaK-2).Results: The prevalence of HDV obtained is estimated at 2.4%. The prevalence ranges from 1% in chronic hepatitis to 11.1% in cirrhotic hepatitis (low endemic area). Seropositivity rate is closely correlated with age (Odds ratio [OR] = 9.98, p = 0.000) and gender (OR = 0.24, p = 0.025); it reaches 58.3% in the age group of 51–60 years and 0% in children (age group 1–15 years); it represents 75% in females and 25% in males. The presence of familial cases of HBsAg positive (OR = 4.54, p = 0.006), the endoscopic procedure (OR = 6.54, p = 0.000) and tattooing (OR = 20, p = 0.000) were found to be the transmission risk factors. A statistically significant relationship was found between the positivity of anti-HDV and advanced liver disease, cirrhosis (OR = 9. 16, p = 0.000). A significant correlation was found between the positivity of anti-HDV with diabetes (OR = 6.83, p = 0.000), obesity (OR = 4.19, p = 0.009) and viral suppression B (OR = 5.69, p = 0.003).Conclusion: Our results show that HDV infection is low in Algeria. Research for total anti-HDV should be part of the initial assessment of patient care with viral hepatitis B as well as the prevalence of other viruses (hepatitis C [HCV] and HIV). A multicentre study should be carried out to know the importance of HDV infection and identify the risk groups. | |
| Publisher | AOSIS Publishing | |
| Date | 2019-10-23 | |
| Identifier | 10.4102/sajid.v34i1.110 | |
| Source | Southern African Journal of Infectious Diseases; Vol 34, No 1 (2019); 6 pages 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajid.co.za/index.php/sajid/article/view/110/180
https://sajid.co.za/index.php/sajid/article/view/110/179
https://sajid.co.za/index.php/sajid/article/view/110/181
https://sajid.co.za/index.php/sajid/article/view/110/178
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