Diagnostic and mortality outcomes in a cohort of adult meningitis suspects in KwaZulu-Natal
Southern African Journal of Infectious Diseases
| Field | Value | |
| Title | Diagnostic and mortality outcomes in a cohort of adult meningitis suspects in KwaZulu-Natal | |
| Creator | Nonkala, Onke Aldous, Colleen Wilson, Douglas | |
| Description | Background: The clinical value of lumbar puncture (LP) in settings with a high human immunodeficiency virus (HIV) prevalence has not been well defined.Methods: We performed a retrospective chart review in 394 adults undergoing LP at a single regional level public-sector hospital in KwaZulu-Natal, South Africa.Results: The median age of all the participants was 32.8 years (interquartile range 26.7; 41.2). Two hundred and fifty-five participants (64.7%) had an abnormal cerebrospinal fluid (CSF) analysis; 202 (79.5%) of whom were HIV seropositive. Sixty-four (25.1%) were diagnosed with tuberculosis meningitis and 62 (24.3%) tested positive for cryptococcal antigen. Thirty-three specimens grew Cryptococcus neoformans (32 tested antigen positive) and Streptococcus pneumonia was isolated in three specimens (0.8%). An abnormal CSF result was associated with increased risk of inpatient death (OR 3.8 [95% CI 1.7; 9.6]; p-value = 0.0004)Conclusions: CSF abnormalities were common in this cohort of adults with suspected meningitis in KwaZulu-Natal, and were associated with increased odds of mortality in hospitalised participants. | |
| Publisher | AOSIS Publishing | |
| Date | 2018-03-31 | |
| Identifier | 10.4102/sajid.v33i1.28 | |
| Source | Southern African Journal of Infectious Diseases; Vol 33, No 1 (2018); 8-11 2313-1810 2312-0053 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajid.co.za/index.php/sajid/article/view/28/23
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