Toxicokinetics of cotyledoside following intravenous administration to sheep
Journal of the South African Veterinary Association
| Field | Value | |
| Title | Toxicokinetics of cotyledoside following intravenous administration to sheep | |
| Creator | Botha, C.J. Rundberget, T. Swan, G.E. Mulders, M.S.G. Flaoyen, A. | |
| Description | Cotyledoside, a bufadienolide cardiac glycoside, was administered intravenously to sheep in 2 studies. In experiment 1, sheep (n = 4) received 0.0135 mg / kg daily on 5 consecutive days and in the 2nd experiment, sheep (n = 4) received 0.027 mg / kg as a single dose. Jugular blood was collected at different time intervals and kinetic parameters were determined. The data fitted a 1-compartmental model. In both experiments a short half-life (t1/2) and mean residence time (MRT), a relative small volume of distribution (Vdss) and rapid clearance were calculated. In the 1st experiment, t1/2 and MRT increased significantly (P 0.007) from Day (D) 0 to D 4. It is suggested that the rapid decline in plasma cotyledoside concentrations in sheep denotes rapid distribution of cotyledoside to the tissues or extracellular spaces and possible accumulation at the biophase. | |
| Publisher | AOSIS | |
| Date | 2003-06-25 | |
| Identifier | 10.4102/jsava.v74i1.488 | |
| Source | Journal of the South African Veterinary Association; Vol 74, No 1 (2003); 7-10 2224-9435 1019-9128 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://jsava.co.za/index.php/jsava/article/view/488/471
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