Die kardiorespiratoriese effek van detomidien in die primaat (Papio ursinus)
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology
| Field | Value | |
| Title | Die kardiorespiratoriese effek van detomidien in die primaat (Papio ursinus) The cardiorespiratory effects of detomidine in the primate (Papio ursinus) | |
| Creator | Bosman, H. | |
| Description | Detomidien is ’n nuwe imidasoolderivaat met ’n hoe affiniteit vir a₂-adrenoseptore. Die kardiorespiratoriese effek van hierdie middel is in primate (Papio ursinus) onder ketamienverdowing geëvalueer. Die vrystelling van noradrenalien word deur a₂-adrenoseptore gemoduleer en gevolglik was die duur van narkose met ketamine gevolg deur detomidien langer as met ketamien alleen. Daar is gevind dat detomidien die hartspoed dramaties vertraag. Hierdie verandering in harttempo was statisties beduidend en is heelwaarskynlik die gevolg van ’n afname in simpatiese uitvloei. Verskeie geleidingsteurnisse het ook voorgekom, heelwaarskynlik ook weens verminderde simpatiese tonus. Die effek van detomidien op die respiratoriese sisteem was minimaal, dit kan dus nuttig gebruik word vir die induksie van narkose in primate waar daar nie fisiologiese studies van die kardiovaskulêre sisteem gedoen word nie. Detomidine is a novel imidazole derivative with a high affinity for a₂-adrenoceptors. The cardiorespiratory effects of this drug were evaluated in the primate (Papio ursinus) under ketamine anaesthesia. The release of noradrenalin is modulated by a₂-adrenoceptors, and this resulted in a longer duration of anaesthesia when ketamine was combined with detomidine in comparison with ketamine alone. Detomidine caused a marked bradycardia, which was not reflex induced, but probably the result of a decreased sympathetic outflow. Various conducting disturbances were observed in the electrocardiogram, also probably the result of decreased sympathetic tone to the heart. The effect of detomidine on the respiratory system was minimal. Detomidine proved to be a useful drug to use in combination with ketamine for the induction of anaesthesia in primates. It should, however, not be used during cardiovascular studies. | |
| Publisher | AOSIS | |
| Date | 1990-07-08 | |
| Identifier | 10.4102/satnt.v9i3.461 | |
| Source | Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 9, No 3 (1990); 116-117 Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 9, No 3 (1990); 116-117 2222-4173 0254-3486 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/461/825
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