Die ontwerp en sintese van ’n belowende reeks piroolkarbaldehiede as potensiële MIV-1 integrase-inhibeerders
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology
| Field | Value | |
| Title | Die ontwerp en sintese van ’n belowende reeks piroolkarbaldehiede as potensiële MIV-1 integrase-inhibeerders The design and synthesis of a pyrrole-carbaldehyde hit family as HIV-1 integrase inhibitors | |
| Creator | Traut, Telisha Hewer, Raymond Coates, Judy Williams, D. Bradley G. | |
| Description | Menslike immuniteitsgebreksvirus tipe 1 (MIV-1) en die geassosiëerde verworweimmuniteitsgebreksindroom (VIGS) toon alreeds ’n ernstige effek op wêreldsgesondheidsvlakke, asook op die wêreldekonomie. Screening of an HIV-1 IN model against database-derived chemical structures identified pyrrole-carbaldehydes as targets for further development. Chemical synthesis using a facile one-pot reaction resulted in the generation of a compound library. Preliminary toxicity and efficacy assays of the water-soluble HCl-salt derivatives of each compound support the in silico predictions. | |
| Publisher | AOSIS | |
| Date | 2011-10-26 | |
| Identifier | 10.4102/satnt.v30i1.268 | |
| Source | Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 30, No 1 (2011); 1 bladsy Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 30, No 1 (2011); 1 bladsy 2222-4173 0254-3486 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/268/292
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/268/311
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/268/294
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/268/267
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