Die verbindings en biologiese aktiwiteit van Thamnosma africana
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology
| Field | Value | |
| Title | Die verbindings en biologiese aktiwiteit van Thamnosma africana The compounds and biological activity of Thamnosma africana | |
| Creator | Mafokane, H. F. Potgieter, N. Van Ree, T. | |
| Description | Die bogrondse dele en vrugte van Thamnosma africana is ontleed vir chemiese bestanddele. Die vlugtige olie van T. africana is verkry deur stoomdistillasie van die blare, blomme en takkies, en deur middel van GC-MS gekarakteriseer. Die olie is vir biologiese aktiwiteit teen E. coli, B. subtilis en S. aureus getoets en het B.subtilis en S. aureus teen 0.1% verdunning geïnhibeer. Die olie was ook aktief in mikromolare konsentrasies teen Plasmodium falciparum. Chromatografiese skeiding van die etielasetaatekstrak van die bogrondse dele het twee metoksipsoralenisomere (xanthotoxin en bergapten) en 6-(1c,2c-dihidroksi-3c-metiel-3c-buteniel)-7-metoksichromen-2-oon (thamnosmonin) opgelewer. Die epoksied van thamnosmonin, 6-(1c,2c-epoksi-3c-metielbut-3c-en-1c-iel)-7-metoksichromen-2-oon (thamnosmin), en metiel-p-isopentenieloksisinnamaat is uit die heksaanekstrak van die vrugte geïsoleer, terwyl nog ƌ furanokumarien, 4,9-dimetoksi-7H-furo[3,2-g]bensopiran-7-oon (isopimpinellin) uit ƌ dichloormetaanekstrak van die bogrondse dele geïsoleer is. The aerial parts and fruits of Thamnosma africana were investigated for chemical compounds present in them. The volatile oil of T. africana was prepared by hydrodistillation of leaves, flowers and stems, and characterized by GC-MS. The oil was tested for antimicrobial activity on cultures of E. coli, B. subtilis and S.aureus, and found to inhibit Bacillus subtilis and Staphylococcus aureus at 0.1% dilution. The oil was also active against Plasmodium falciparum in micromolar concentrations. Chromatographic separation of the ethyl acetate extract of the aerial parts yielded two isomers of methoxypsoralen (xanthotoxin and bergapten) and 6-(1c,2c-dihydroxy-3c-methyl-3c-butenyl)-7-methoxychromen-2-one (thamnosmonin). The epoxide of thamnosmonin, 6-(1c,2c-epoxy-3c-methylbut-3c-en-1c-yl)-7-methoxychromen-2-one (thamnosmin), and methyl p-isopentenyloxycinnamate were isolated from the hexane extract of the fruits, while another furanocoumarin, 4,9-dimethoxy-7H-furo[3,2-g]benzopyran-7-one (isopimpinellin) was isolated from a dichloromethane extract of the aerial parts. | |
| Publisher | AOSIS | |
| Date | 2006-09-22 | |
| Identifier | 10.4102/satnt.v25i3.154 | |
| Source | Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 25, No 3 (2006); 138-148 Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 25, No 3 (2006); 138-148 2222-4173 0254-3486 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/154/125
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