In vitro seintransduksie meganisme uitgeoefen deur 2-etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol- 17-een in kombinasie met ‘n dichloro-asetielsuur op die bors adenokarsinoom (MCF-7) en bors nie-tumorigene (MCF-12A) selle

Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology

 
 
Field Value
 
Title In vitro seintransduksie meganisme uitgeoefen deur 2-etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol- 17-een in kombinasie met ‘n dichloro-asetielsuur op die bors adenokarsinoom (MCF-7) en bors nie-tumorigene (MCF-12A) selle In vitro signal transduction mechanism exerted by 2-ethyl-3- O -sulphamoyl-estra-1,3,5(10), 15-tetraen-3-ol-17-one in combination with dichloroacetic acid on breast adenocarcinoma (MCF-7) and breast non-tumorigenic (MCF-12A) cells
 
Creator Stander, X. X. Stander, A. Joubert, A.
 
Subject — — — —
Description 2-Etiel-3-O-sulphamoyl-estra-1,3,5(10),15-tetraen-3-ol-17 (C9) is ‘n nuwe,in silico-ontwerpte, antimitotiese 17-beta-estradiolderivaat. Dichloro-asetielsuur (DCA) inhibeer pirovaat dehydrogenase kinase ensiem aktiwiteit wat die vorming en vervoer van asetiel-KoA in die mitochondria inhibeer. Dit veroorsaak dat fermentasie prosesse, wat in kankerselle bevoordeel word, onderdruk word. In vitro evaluation of a novel antimitotic estradiol analog and dichloroacetate in breast adenocarcinoma and breast non-tumorigenic cells will contribute to the field of combination therapy in cancer.
 
Publisher AOSIS
 
Contributor — —
Date 2012-06-06
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — — — —
Format text/html application/pdf
Identifier 10.4102/satnt.v31i1.343
 
Source Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 31, No 1 (2012); 1 bladsy Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 31, No 1 (2012); 1 bladsy 2222-4173 0254-3486
 
Language eng
 
Relation
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://journals.satnt.aosis.co.za/index.php/satnt/article/view/343/505 https://journals.satnt.aosis.co.za/index.php/satnt/article/view/343/454
 
Coverage — — — — — —
Rights Copyright (c) 2012 X. X. Stander, A. Stander, A. Joubert https://creativecommons.org/licenses/by/4.0
ADVERTISEMENT

International Tel: 021 975 2602

15 Oxford street, Durbanville, Cape Town, 7550 (South Africa)
Copyright © AOSIS (Pty) Ltd. All rights reserved.
No unauthorised duplication allowed