Die toksisiteit van Gladiolus dalenii van Geel
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology
| Field | Value | |
| Title | Die toksisiteit van Gladiolus dalenii van Geel The toxicity of Gladiolus dalenii van Geel | |
| Creator | van Dyk, S. Gerritsma- Van der Vijver, L. M. van der Nest, D. G. | |
| Description | Die biologiese aktiwiteit van Gladiolus dalenii van Geel (Iridaceae) knolle (etnomedies gebruik) en blare is in ’n aantal sisteme geëvalueer. ’n Profiel van die akute toksisiteit in rotte is saamgestel en bevindings is dat sowel knolle as blare sitotoksiese verbindings wat mitoties aktiewe weefsel aantas, bevat. Akute sterftes is die gevolg van kongestiewe hartversaking. ’n Fraksie (gekodeer as GDI) geïsoleer uit knolle toon kwalitatief dieselfde toksisiteit as knolle en blare. Die beraamde gebied vir minimum letale dosisse (MLD), uitgedruk as mg/kg-liggaamsmassa, wisselvan 10-31 intraperitoneaal (i.p.) en 3 160-5 620 oraal (p.o.) vir knolle, 100-316(i.p.) en 1 780 (p.o.) vir blare en 1-3 (i.p.) en l 000 (p.o.) vir fraksie GDI. Heel plantmateriaal het geen aktiwiteit teen ’n reeks mikro-organismes getoon nie. Fraksie GDI was aktief teen Candida albicans. Fototoksisiteit kon nie aangetoon word nie. The biological activity of Gladiolus dalenii van Geel (Iridaceae) corms (used in ethnomedicine) and leaves were evaluated in a few systems. A profile of acute toxicity in rats was compiled and it was found that both corms and leaves contained cytotoxic substances affecting mitotic active tissue. Acute deaths resulted from congestive heart failure. The toxicity of a fraction (coded as GDI) isolated from corms was qualitatively similar to that of corms and leaves. Estimated minimum lethal doses, given in mg/kg body weight, lie in the range 10-31 (i.p.) and 3 160 - 5 620 (p.o.) for corms, 100-316 (i.p.) and 1 780 (p.o.) for leaves and 1-3 (i.p.) and 1 000 (p.o.) for fraction GDI. Intact plant material showed no activity against a series of microbes. Fraction GDI was active against Candida albicans. Phototoxicity was not detected. | |
| Publisher | AOSIS | |
| Date | 1994-07-10 | |
| Identifier | 10.4102/satnt.v13i4.594 | |
| Source | Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 13, No 4 (1994); 125-128 Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 13, No 4 (1994); 125-128 2222-4173 0254-3486 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/594/1068
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