Die effekte van melatonien op molekulêre vlak

Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology

 
 
Field Value
 
Title Die effekte van melatonien op molekulêre vlak The effects of melatonin on a molecular level
 
Creator Haag, M. Theron, J. J.
 
Subject — — — —
Description Die indoolhormoon melatonien word volgens 'n bifasiese sirkadiese ritme deur die pineaalklier afgeskei. Hierdie oorsigartikel bied ’n opsomming van onlangse resultate oor: (i) faktore wat melatoniensekresie beinvloed; (ii) die bestaan van melatonienreseptore in breinweefsel; (Hi) effekte van melatonien as ’n moduleerder van dopaminergiese, noradrenergiese, GABA-ergiese en opioiedergiese neuro- oordragsprosesse; (iv) die invloed van melatonien op elektriese aktiwiteit en metaboliese snelheid van sekere breinkerne; asook (v) melatonieneffekte op hormoonafskeiding in die hipotalamus-hipofise-as. ’n Grondliggende meganisme van melatonienwerking deur middel van sikliese nukleotiede en proteienfosforilering word verder voorgestel. The indole hormone melatonin is secreted in a biphasic circadian rhythm by the pineal gland. This review presents a summary of recent results concerning — (i) factors that influence melatonin synthesis; (ii) the existence of melatonin receptors in brain tissue; (iii) the effects of melatonin as a modulator of dopaminergic, noradrenergic, GABAergic and opioidergic neurotransmitter processes; (iv) the influence of melatonin on the electric activity and metabolic rate of certain brain nuclei; and (v) melatonin effects on hormone secretion in the hypothalamic-pituitary axis. A basic mechanism of melatonin action via cyclic nucleotides and thus protein phosphorylation is presented.
 
Publisher AOSIS
 
Contributor — —
Date 1992-07-08
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — — — —
Format application/pdf
Identifier 10.4102/satnt.v11i1.515
 
Source Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 11, No 1 (1992); 14-19 Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 11, No 1 (1992); 14-19 2222-4173 0254-3486
 
Language eng
 
Relation
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://journals.satnt.aosis.co.za/index.php/satnt/article/view/515/924
 
Coverage — — — — — —
Rights Copyright (c) 1992 M. Haag, J. J. Theron https://creativecommons.org/licenses/by/4.0
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