Sirkadiese fluktuasies in serumserotonienkonsentrasies van normale gesonde mans
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology
| Field | Value | |
| Title | Sirkadiese fluktuasies in serumserotonienkonsentrasies van normale gesonde mans Circadian fluctuations in serum serotonin concentrations of normal, healthy men | |
| Creator | Office, Editorial | |
| Description | Sirkadiese sekresiepatrone vir bykans alle hormone/neuro-oordragstowwe is welbekend en hou in vele gevalle biologies onderling verband. Serotonien (5-Hidroksitriptamien, 5-HT) kom wydverspreid sentraal asook perifeer in die menslike liggaam voor (pineaalklier, raphékerne van die breinstam, serotoninergiese senuweevesels van enteriese pleksusse, bloedvate en in bloedplaatjies). Meer as 90% van die serotonien in die menslike liggaam kom egter in die enterochromaffienselle van die gastro-intestinale kanaal voor. The biogenic amine, serotonin (5-HT), is synthesized from tryptophan (an essential amino acid) and acts multipotent as neurotransmitter/neuromodulator/hormone/precursor for methoxy-indole compounds such as N-acetyl-5-methoxytryptamine (melatonin). The circadian secretion pattern of melatonin is well known. Circadian fluctuations in pineal gland (“central”) concentrations of 5-HT have already been reported in literature. Since information with regard to possible circadian fluctuations in “peripheral" (plasma/serum) serotonin concentrations is scanty, the main objective of this study was to ascertain whether such fluctuations do in fact occur. Serum serotonin concentrations were determined in blood samples obtained hourly from twelve healthy male subjects during a period of 24 hours. The results clearly suggest a triphasic secretion pattern for serum serotonin. (The said circadian secretion tendency does not correspond with that of any determinable 5-HT metabolite). | |
| Publisher | AOSIS | |
| Date | 1993-07-09 | |
| Identifier | 10.4102/satnt.v12i2.559 | |
| Source | Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 12, No 2 (1993); 44-46 Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 12, No 2 (1993); 44-46 2222-4173 0254-3486 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/559/999
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