The primary structure of a short neurotoxin homologue from Dendroaspis polylepis polylepis (Black mamba) venom
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie/South African Journal of Science and Technology
| Field | Value | |
| Title | The primary structure of a short neurotoxin homologue from Dendroaspis polylepis polylepis (Black mamba) venom Die primêre struktuur van ’n kort neurotoksienhomoloog uit die gif van Dendroaspis polylepis polylepis (Swartmamba) | |
| Creator | Joubert, F. J. | |
| Description | Toxin CM-7 was purified from black mamba venom by gel filtration on Sephadex G-50 followed by ion exchange chromotography on CM-cellulose. It contains 60 amino acids, including eight half-cystines. The complete amino acid sequence of toxin CM-7 has been elucidated. In toxin CM-7 the eleven structurally invariant amino acids of the neurotoxins and cardiotoxins are conserved, but it has only one of the five functionally invariant amino acids of the neurotoxins. The eight cysteine residues of toxin CM-7 are in the same locations as those in short neurotoxins of known structures and are presumed to be similarly cross-linked. The sequence of CM-7 is structurally homologous with the short neurotoxins, but it is less toxic. Toksien KM-7 is suiwer uit swartmambagif verkry deur middel van jelfiltrering op Sephadex G-50, gevolg deur ioonuitruilchromatografie op KM-selluiose. Die toksien bevat 60 aminosure, waaronder agt halfsistienreste, en die volledige aminosuurvolgorde is bepaal. Die toksien bevat al elf struktureel konstante aminosure van die kort neurotoksiene en kardiotoksiene, maar net een van die vyf funksioneel konstante aminosure van die kort neurotoksiene. Die agt sisteïenreste van KM-7 kom in dieselfdeposisies as die van kort neurotoksiene met bekende strukture voor en is waarskynlik eenders kruisgebind. Hoewei die volgorde van KM-7 struktureel soortgelyk aan die van die kort neurotoksiene is, is dit minder gif tig. | |
| Publisher | AOSIS | |
| Date | 1984-03-20 | |
| Identifier | 10.4102/satnt.v3i3.1084 | |
| Source | Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 3, No 3 (1984); 169-174 Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie; Vol 3, No 3 (1984); 169-174 2222-4173 0254-3486 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://journals.satnt.aosis.co.za/index.php/satnt/article/view/1084/2215
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