Polyphenolic constituents, antioxidant and hypoglycaemic potential of leaf extracts of Acalypha godseffiana from Eastern Nigeria: In vitro study

Journal of Medicinal Plants for Economic Development

Field Value
Title Polyphenolic constituents, antioxidant and hypoglycaemic potential of leaf extracts of Acalypha godseffiana from Eastern Nigeria: In vitro study
Creator Asekunowo, Anita K. Ashafa, Anofi O.T. Okoh, Omobola Asekun, Olayinka T. Familoni, Oluwole B.
Subject — Acalypha godeseffiana; phytochemicals; antioxidant; acetone extract; hypoglycemic
Description Background: Acalypha godseffiana is an important plant used as an ornamental and herbs; its leaves are used in the management of diseases like diabetes in Eastern Nigeria.Aim: The study aims at linking the hypoglycemic activity extracts of leaves of A. godseffiana to their polyphenolic contents.Setting: Fresh leaves of A. godseffiana were obtainedfrom Imo State, Nigeria, identified in University of Lagos Herbarium, air-dried, pulverized and kept for investigations.Method: The phytochemical compositions and antioxidant potentials of acetone, aqueous, ethanol and methanol extracts of A. godseffiana were determined using adopted methods. An in-vitroapproach was used to evaluate the hypoglycemic potentials of the extracts on α-amylase and α-glucosidase enzymes. The mechanism of inhibitions was studied using the Lineweaver-Burk plot.Results: Antioxidant results revealed that total antioxidant capacity of the acetone extract (IC50: 0.34 mg/mL) showed better activity compared to the standards (silymarin 0.52 mg/mL; gallic acid 0.51 mg/mL). Thehypoglycemic findings confirmed that acetone extract demonstrated strong and mild inhibitory potential against α-amylase and α-glucosidase respectively, showing concentration dependent with IC50 values of 2.33 mg/mL and 0.13 mg/mL. The observed hypoglycemic and antioxidant potentials of acetone extract of A. godseffiana correlate to its high polyphenolic contents which include phenols (133.20 mg gallic acid g-1), flavonoid (350.60 mg quercetin g-1) and tannins (264.67 mg catechin g-1). The mechanisms of action exhibited by the acetone extractwere uncompetitive and mixed non-competitive which can be attributed to its inhibitory properties on α-glucosidase and α-amylase respectively.Conclusion: The results obtained from this study validate the acetone leaves extract of A. godseffiana as potential agent in management of sugar related disorder.
Publisher AOSIS Publishing
Date 2019-01-23
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip application/xml application/pdf
Identifier 10.4102/jomped.v3i1.36
Source Journal of Medicinal Plants for Economic Development; Vol 3, No 1 (2019); 9 pages 2616-4809 2519-559X
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://jomped.org/index.php/jomped/article/view/36/175 https://jomped.org/index.php/jomped/article/view/36/174 https://jomped.org/index.php/jomped/article/view/36/176 https://jomped.org/index.php/jomped/article/view/36/173
Coverage — — —
Rights Copyright (c) 2019 Anita K. Asekunowo, Anofi O. T. Ashafa, Omobola Okoh, Olayinka T. Asekun, Oluwole B. Familoni https://creativecommons.org/licenses/by/4.0