Antidiabetic and anti-oxidant activities of the methanol leaf extract of Vernonia amygdalina in alloxan-induced diabetes in Wistar rats

Journal of Medicinal Plants for Economic Development

Field Value
Title Antidiabetic and anti-oxidant activities of the methanol leaf extract of Vernonia amygdalina in alloxan-induced diabetes in Wistar rats
Creator Adeoye, Adegbolagun T. Oyagbemi, Ademola A. Adedapo, Aduragbenro D. Omobowale, Temidayo O. Ayodele, Abiodun E. Adedapo, Adeolu A.
Subject Ethnopharmacology Diabetes; Vernonia amygdalina; alloxan; anti-oxidant; hyperglycaemia; glibenclamide
Description The methanolic leaf extract of Vernonia amygdalina (MLVA) was assessed to evaluate its antidiabetic potential in rats. Diabetes was induced in male Wistar rats by the administration of alloxan monohydrate at 100 mg/kg of body weight. After 48 h, rats with fasting blood glucose levels of 200 mg/dL and above were considered diabetic and used for the study. The experimental animals were grouped into five groups (A–E) of 10 animals each. Group A rats were non-diabetic normal control, Group B consisted of diabetic control rats that received no treatment, groups C, D and E rats were diabetic rats but treated with glibenclamide, 200 and 400 mg/kg doses of MLVA respectively. Blood samples were collected at days 14 and 28 after induction for haematological and serum biochemical indices such as triglycerides, LDL, cholesterols etc. The intestine was collected and intestinal homogenate was prepared for the antioxidant studies. The extract at 200 mg/kg and 400 mg/kg doses significantly (p  0.05) reduced blood glucose levels in extract-treated diabetic rats and also significantly increased weight gain in these rats. Most haematological parameters in treated rats experienced, while platelets and neutrophils were decreased. Biochemical indices measured were reduced in MLVA-treated groups compared with diabetic control. Treatment with MLVA also produced significant (p  0.05) decrease in markers of oxidative stress but increased levels of enzymic and non-enzymic antioxidant markers in intestinal homogenates of treated groups compared with diabetic control. This study showed that V. amygdalina has antihyperglycaemic and in vivo antioxidant effects.
Publisher AOSIS Publishing
Date 2017-12-21
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Qualitative research
Format text/html application/epub+zip application/xml application/pdf
Identifier 10.4102/jomped.v1i1.30
Source Journal of Medicinal Plants for Economic Development; Vol 1, No 1 (2017); 12 pages 2616-4809 2519-559X
Language eng
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Coverage Africa — —
Rights Copyright (c) 2017 Adegbolagun T. Adeoye, Ademola A. Oyagbemi, Aduragbenro D. Adedapo, Temidayo O. Omobowale, Abiodun E. Ayodele, Adeolu A. Adedapo