Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management

Journal of Insulin Resistance


 
 
Field Value
 
Title Diabetes mellitus: A review of some of the prognostic markers of response to treatment and management
 
Creator Agu, Kingsley C.
 
Subject insulin resistance; diabetes mellitus; hyperglycemia; biomarkers diabetes mellitus; biomarkers; glycated hemoglobin; hyperglycemia; complications
Description Background: The WHO defined ‘diabetes mellitus’ (DM) as a metabolic disorder characterised by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from the defect in insulin secretion, or inaction, or both. When not identified early and controlled, acute and chronic life-threatening consequences may result. Identifying DM early for treatment and management, as well as clinically monitoring recovery and improvement during treatment, involves the assessments of biomarkers. The types, choice, sensitivity and descriptive information trends of these biomarkers are very important. Aim: Some prognostic biomarkers and parameters that this review identified include glycated haemoglobin, white blood cells, mean neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, total leukocytes and neutrophils, plasma low-density lipoprotein, high-density lipoprotein and very low-density lipoprotein, platelet, fibrinogen, D-dimer and C-reactive proteins. Results: These parameters display increases in DM, while red blood cell, haemoglobin concentration, activated partial thromboplastin time, prothrombin time and partial thromboplastin time are decreased. Conclusion: With sound knowledge of the variations of these markers and parameters, observed reversal during treatment and management of DM and its complications can be better monitored, and guided decisions can be made.
 
Publisher AOSIS
 
Contributor Department of Medical Biochemistry
Date 2018-06-25
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — review; survey; qualitative research
Format text/html application/epub+zip application/xml application/pdf
Identifier 10.4102/jir.v3i1.36
 
Source Journal of Insulin Resistance; Vol 3, No 1 (2018); 10 pages 2519-7533 2412-2785
 
Language eng
 
Relation https://insulinresistance.org/index.php/jir/article/view/36/125 https://insulinresistance.org/index.php/jir/article/view/36/124 https://insulinresistance.org/index.php/jir/article/view/36/126 https://insulinresistance.org/index.php/jir/article/view/36/123
 
Coverage Africa; South Africa; Nigeria 2005-2018 diabetes mellitus; biomarkers; glycated hemoglobin; hyperglycemia; complications
Rights Copyright (c) 2018 Kingsley Chukwunonso AGU https://creativecommons.org/licenses/by/4.0