The contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome

Journal of Insulin Resistance


 
 
Field Value
 
Title The contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome
 
Creator Pateguana, Nadia B. Janes, Alvin
 
Subject — PCOS; hyperandrogenemia; hyperinsulinemia; fertility; insulin resistance
Description Background: Polycystic Ovary Syndrome (PCOS) is a very common endocrine disorder of young women.Aim: The proper treatment of PCOS requires a thorough understanding of the underlying cause of disease. In this article, we review the extent to which hyperinsulinemia contributes to the development of PCOS.Setting: The goal of this review was to assess the current literature on the contribution of hyperinsulinemia to the hyperandrogenism of polycystic ovary syndrome in hopes of promoting future research and advancements in clinical treatments for women with PCOS focusing on this major contributing factor, hyperinsulinemia.Method: A review of published peer-reviewed literature was conducted by searching the keywords.Results: Excessive insulin causes both the overproduction of testosterone and decreased sex hormone binding globulin (SHBG) levels seen in PCOS, both of which collaborate in creating an increased testosterone effect.Conclusion: The majority of research and evidence shows that the hyperandrogenism of PCOS is likely caused by hyperinsulinemia. Yet the conventional treatment of hyperandrogenic symptoms in women with PCOS is not directed towards correcting this underlying hyperinsulinemia. Further research is needed to assess how the treatment of the hyperinsulinemia through lifestyle would compare to the current treatment of hyperandrogenemia through testosterone-lowering drugs.
 
Publisher AOSIS
 
Contributor
Date 2019-07-02
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip application/xml application/pdf
Identifier 10.4102/jir.v4i1.50
 
Source Journal of Insulin Resistance; Vol 4, No 1 (2019); 3 pages 2519-7533 2412-2785
 
Language eng
 
Relation https://insulinresistance.org/index.php/jir/article/view/50/184 https://insulinresistance.org/index.php/jir/article/view/50/183 https://insulinresistance.org/index.php/jir/article/view/50/185 https://insulinresistance.org/index.php/jir/article/view/50/182
 
Coverage — — —
Rights Copyright (c) 2019 Nadia B. Pateguana, Alvin Janes https://creativecommons.org/licenses/by/4.0