Association between PNPLA8 gene polymorphism and schizophrenia in male patients
South African Journal of Psychiatry
| Field | Value | |
| Title | Association between PNPLA8 gene polymorphism and schizophrenia in male patients | |
| Creator | Yu, Qiong Yu, Yaqin Shi, Jieping Sang, Hong | |
| Description | Abnormal phospholipid metabolism in the brain plays an important role in neuropsychiatric diseases. Phospholipase A2 is crucial for maintaining normal neuro-physiological function. The aim of this study was to investigate the association between polymorphisms of the membrane-associated calcium-independent phospholipase A2 gamma (PNPLA8) gene and schizophrenia in Han Chinese in north China. The PCR-based ligase detection reaction was applied to detect 3 single nucleotide polymorphisms (SNPs) in the PNPLA8 gene among 201 Chinese pedigrees. The genotypic frequency of the PNPLA8 polymorphisms did not deviate from the Hardy-Weinberg equilibrium both in affected offspring and parental groups. Haploid relative risk (HRR) and transmission disequilibrium tests (TDT) showed that the 3 SNPs were not associated with schizophrenia (p0.05), but further analysis with TDT showed that the rs40876 polymorphism was associated with schizophrenia in males (χ2=4.667, p=0.031). Our data suggest that rs40876 in PNPLA8 may be associated with schizophrenia in males. | |
| Publisher | AOSIS | |
| Date | 2013-08-30 | |
| Identifier | 10.4102/sajpsychiatry.v19i3.455 | |
| Source | South African Journal of Psychiatry; Vol 19, No 3 (2013); 2 2078-6786 1608-9685 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajp.org.za/index.php/sajp/article/view/455/428
https://sajp.org.za/index.php/sajp/article/view/455/414
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