Changing the course of schizophrenia - predictors of treatment outcome revisited

South African Journal of Psychiatry

Field Value
Title Changing the course of schizophrenia - predictors of treatment outcome revisited
Creator Emsley, R Oosthuizen, P Niehaus, D Koen, L Chiliza, B
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Description Multiple factors play a role in determining the outcome of schizophrenia. However, the role of these factors is poorly understood, and research findings so far have been inconclusive and sometimes contradictory. Various demographic and baseline clinical factors have been reported to be associated with treatment outcome. Also, early symptom reduction after initiation of antipsychotic therapy is closely related to later treatment response. However, associations as such do not necessarily imply predictive value, and none of these factors can be regarded as clinically useful in predicting treatment outcome. This article discusses selected aspects of treatment outcome and its prediction in schizophrenia, focusing particularly on early treatment response, ethnicity, neurological soft signs, and the predictive value of a discriminant functional analysis model utilising a combination of putative predictors. Such a model holds promise, and it is to be hoped that future refinements will lead to a clinically useful model for predicting outcome.
Publisher AOSIS
Date 2007-02-01
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format application/pdf
Identifier 10.4102/sajpsychiatry.v13i1.4
Source South African Journal of Psychiatry; Vol 13, No 1 (2007); 5 2078-6786 1608-9685
Language eng
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Rights Copyright (c) 2007 R Emsley, P Oosthuizen, D Niehaus, L Koen, B Chiliza