Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection

South African Journal of Psychiatry


 
 
Field Value
 
Title Neuropsychiatric symptoms and diagnosis of grey matter heterotopia: A case-based reflection
 
Creator Lippi, Gian
 
Subject Psychiatry Grey matter heterotopia; Schizophrenia; neuronal migration
Description Neuropsychiatric symptoms can be related to less common underlying neuropsychiatric conditions – in this case report, the condition discussed is that of grey matter heterotopia (GMH). The patient presented with a history of prominent aggression, impulsivity and manipulative and attention-seeking behaviour. Episodes of depression and incidents of deliberate self-harm and suicide attempts had been reported. Neuropsychiatric symptoms included anxiety, a labile mood, delusional thinking and auditory hallucinations. Testing revealed some cognitive difficulties and severe impairment of frontal lobe functions. A magnetic resonance imaging (MRI) scan of his brain revealed the presence of GMH, which had previously been misdiagnosed as tuberous sclerosis. An MRI scan of the brain is the special investigation of choice for the correct diagnosis of GMH. The pathognomonic finding is that of heterotopic grey matter abnormally located within areas of white matter. Defective foetal neuronal migration between the third and fifth month of pregnancy can lead to GMH, which can present later on in childhood or adolescence with epilepsy, intellectual impairment or reading difficulties. During the late teenage years or early adulthood, a wide variety of neuropsychiatric symptoms may be present, which can lead to diagnostic difficulties.
 
Publisher AOSIS
 
Contributor
Date 2017-03-28
 
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — —
Format text/html application/epub+zip application/xml application/pdf
Identifier 10.4102/sajpsychiatry.v23i0.923
 
Source South African Journal of Psychiatry; Vol 23 (2017); 6 pages 2078-6786 1608-9685
 
Language eng
 
Relation https://sajp.org.za/index.php/sajp/article/view/923/804 https://sajp.org.za/index.php/sajp/article/view/923/803 https://sajp.org.za/index.php/sajp/article/view/923/805 https://sajp.org.za/index.php/sajp/article/view/923/802
 
Coverage South Africa — —
Rights Copyright (c) 2017 Gian Lippi https://creativecommons.org/licenses/by/4.0