Overview of HIV-related lipodystrophy

Southern African Journal of HIV Medicine

Field Value
Title Overview of HIV-related lipodystrophy
Creator Rossouw, T Marie Botes, M E Conradie, F
Subject Medicine; Infectious Diseases HIV; Lipodystrophy; Metabolic complications HIV treatment and complications
Description Lipodystrophy is a well-recognised adverse effect of HIV and antiretroviral therapy, with certain antiretrovirals, specifically thymidine analogues, implicated in the aetiology and pathogenesis. Lipodystrophy is often accompanied by metabolic complications, such as hyperlipidaemia and insulin resistance, which increase risk for cardiovascular disease. There are limited data on the effect of treatment modification, pharmacological interventions and surgical management on this condition.
Here we summarise the latest data on lipodystrophy, with the aim of facilitating informed decision-making in managing this condition. In light of the absence of cost-effective measures to treat lipoatrophy and lipohypertrophy, prevention remains the best option; we recommend targeted annual screening. Healthcare workers should be sensitised to early detection in patients on thymidine-based regimens, and affected patients should be switched to an appropriate regimen as soon as feasible. There is no evidence to support the use of new-generation ARVs, except in patients with significant hypercholesterolaemia, where atazanavir and raltegravir may present better options.

S Afr J HIV Med 2013;14(1):29-33. DOI:10.7196/SAJHIVMED.871
Publisher AOSIS
Date 2013-02-26
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Review of literature
Format text/html application/pdf
Identifier 10.4102/sajhivmed.v14i1.100
Source Southern African Journal of HIV Medicine; Vol 14, No 1 (2013); 29-33 2078-6751 1608-9693
Language eng
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:

https://sajhivmed.org.za/index.php/hivmed/article/view/100/161 https://sajhivmed.org.za/index.php/hivmed/article/view/100/160 https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/100/39 https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/100/40 https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/100/41
Coverage Southern Africa N/A N/A
Rights Copyright (c) 2013 T Marie Rossouw, M E Botes, F Conradie https://creativecommons.org/licenses/by/4.0