Routine cranial computed tomography before lumbar puncture in HIV-positive adults presenting with seizures at Mitchells Plain Hospital, Cape Town
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Routine cranial computed tomography before lumbar puncture in HIV-positive adults presenting with seizures at Mitchells Plain Hospital, Cape Town | |
| Creator | Moolla, Salma Rajkumar, Ashmitha de Vries, Elma | |
| Description | Background: Current international guidelines recommend that a cranial computed tomography (CT) be performed on all HIV-positive patients presenting with new onset seizures, before a lumbar puncture (LP) is performed. In the South African setting, however,this delay could be life threatening. The present study sought to measure the number of cranial CTs that contraindicate an LP and to predict which clinical signs and symptoms are likely to pose an increased risk from LP.Methods: The study was performed at a district level hospital in Western Cape Province. Data were collected retrospectively from October 2013 to October 2014. Associations between categorical variables were analysed using Pearson’s chi-squared test. Generalised linear regression was used to estimate prevalence ratios.Results: One hundred out of 132 patients were studied. Brain shift contraindicated an LP in 5% of patients. Patients with brain shift presented with decreased level of consciousness, focal signs, headache and neck stiffness. Twenty-five per cent of patients had a space-occupying lesion (SOL) (defined as a discrete lesion that has a measurable volume) or cerebral oedema. Multivariate analysis showed a CD4 count 50 (p = 0.033) to be a statistically significant predictor of patients with SOL and cerebral oedema. Univariate analysis showed focal signs (p = 0.0001), neck stiffness (p = 0.05), vomiting (p = 0.018) and a Glascow Coma Scale (GCS) 15 (p = 0.002) to be predictors of SOL and cerebral oedema.Conclusion: HIV-positive patients with seizures have a high prevalence of SOL and cerebral oedema but the majority of them are safe for LP. Doctors can use clinical parameters to determine which patients can undergo immediate LP. | |
| Publisher | AOSIS | |
| Date | 2015-07-03 | |
| Identifier | 10.4102/sajhivmed.v16i1.354 | |
| Source | Southern African Journal of HIV Medicine; Vol 16, No 1 (2015); 7 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/354/540
https://sajhivmed.org.za/index.php/hivmed/article/view/354/541
https://sajhivmed.org.za/index.php/hivmed/article/view/354/542
https://sajhivmed.org.za/index.php/hivmed/article/view/354/527
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