Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Reasons for failure of prevention of mother-to-child HIV transmission in a rural South African district hospital | |
| Creator | Kendall, Clifford Claessens, Lore Dorward, Jienchi Mfeka, Gloria Gate, Kelly | |
| Description | Further reduction of mother-to-child transmission (MTCT) of HIV requires improved understanding of the reasons for MTCT. We reviewed maternal and infant case notes for HIV- positive infants diagnosed by polymerase chain reaction at Bethesda Hospital. Nineteen cases were analysed. Median gestation at first antenatal consultation (ANC) was 22.5 (interquartile range [IQR] 19.25–24). Eleven (57.9%) mothers were HIV positive at first ANC, whilst eight tested negative and later positive (2 antepartum, 6 postpartum). Median maternal CD4 was 408 cells/μL (IQR 318–531). Six (31.6%) received no antenatal antiretroviral therapy (ART) because they were diagnosed as HIV positive postpartum; 9 (47.3%) received antenatal ART and 3 (15.8%) were never initiated on ART. At 6 weeks postpartum, 5 infants (26.3%) were not on prophylactic nevirapine (NVP) because their mothers had not yet been diagnosed. Maternal seroconversion in pregnancy and breastfeeding, and possibly false-negative HIV tests, were important reasons for prevention of mother-to-child transmission (PMTCT) failure. | |
| Publisher | AOSIS | |
| Date | 2015-04-28 | |
| Identifier | 10.4102/sajhivmed.v16i1.365 | |
| Source | Southern African Journal of HIV Medicine; Vol 16, No 1 (2015); 3 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/365/481
https://sajhivmed.org.za/index.php/hivmed/article/view/365/482
https://sajhivmed.org.za/index.php/hivmed/article/view/365/483
https://sajhivmed.org.za/index.php/hivmed/article/view/365/470
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