The diagnostic value of lymph node biopsy to detect Castleman’s disease

Southern African Journal of HIV Medicine

Field Value
Title The diagnostic value of lymph node biopsy to detect Castleman’s disease
Creator Soma, Prashilla Kara, Sita
Subject Medicine; Infectious Diseases HIV; Lymph node biopsy; Castleman's disease HIV
Description HIV is not indicated in the aetiology of Castleman’s disease. However, it impacts on the prevalence and natural history of this disease and significantly on the disease progression. Castleman’s disease is a uni- or multicentric disease of the lymph node with or without polyclonal proliferation of B-cells. It is a morphologically distinct form of lymph node hyperplasia and is characterised by significant architectural changes in all lymphatic compartments. Histopathologically, the disease is classified into two major subtypes: the hyaline-vascular type and the plasma-cell type. A mixed type is also identified, as there are frequent transitions between the types. The diagnosis of Castleman’s disease needs to be made histologically. Treatment modalities include surgery, which is curative for unicentric disease, and systemic therapy, which is needed for multicentric disease. This case highlights the diagnostic value of lymph node excision biopsy in HIV-infected patients. 
Publisher AOSIS
Date 2014-09-08
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — Case report
Format application/pdf
Identifier 10.4102/sajhivmed.v15i3.12
Source Southern African Journal of HIV Medicine; Vol 15, No 3 (2014); 110-111 2078-6751 1608-9693
Language eng
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Coverage South Africa 2013 49; Male
Rights Copyright (c) 2014 Prashilla Soma, Sita Kara