Neuroendocrine tumour in a patient with neurofibromatosis type 1 and HIV

Southern African Journal of HIV Medicine

Field Value
Title Neuroendocrine tumour in a patient with neurofibromatosis type 1 and HIV
Creator Hiesgen, Juliane Variava, Ebrahim
Subject Medicine; Phakomatoses; HIV; Malignancies Phakomatoses; HIV; malignancies
Description We report the case of an HIV-positive female patient with neurofibromatosis type 1 who wastreated for recurrent peptic ulcer disease and later developed diabetes mellitus and chronicdiarrhoea. A metastasising somatostatinoma was histologically proven and evidence of aconcomitant gastrin-producing neuroendocrine tumour was found. Neuroendocrine tumours (NETs) are very rare neoplasms originating from a wide variety of endocrine and nervoussystem tissue with the ability to produce different hormones. A somatostatin- and gastrinsecreting NET in a patient with HIV has not been reported in the literature, to the best ofour knowledge. We discuss oncogenic pathomechanisms related to the underlying conditionsand propose stringent monitoring for tumours in HIV-positive patients with phakomatoses aswell as initiation of antiretroviral therapy.
Publisher AOSIS
Contributor Dr. A. Mochan Dr. Tanvier Omar
Date 2015-06-26
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion — case report
Format text/html application/octet-stream text/xml application/pdf
Identifier 10.4102/sajhivmed.v16i1.323
Source Southern African Journal of HIV Medicine; Vol 16, No 1 (2015); 4 pages 2078-6751 1608-9693
Language eng
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Rights Copyright (c) 2015 Juliane Hiesgen, Ebrahim Variava