Associations of visceral fat thickness and anthropometric measurements with non-alcoholic fatty liver disease development in male patients mono-infected with human immunodeficiency virus
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Associations of visceral fat thickness and anthropometric measurements with non-alcoholic fatty liver disease development in male patients mono-infected with human immunodeficiency virus | |
| Creator | Vujanović, Miloš Brkić-Jovanović, Nina Ilić, Dalibor Drvendžija, Zorka Srdić-Galić, Biljana Turkulov, Vesna Brkić, Snežana Marić, Daniela | |
| Description | Background: Non-alcoholic fatty liver disease (NAFLD) represents the most common form of chronic liver disease in mono-infected (without concomitant hepatitis B and/or C virus infection) people living with human immunodeficiency virus (HIV). The proper and on time identification of at-risk HIV-positive individuals would be relevant in order to reduce the rate of progression from NAFLD into non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma.Objectives: The aim of this study was to explore visceral fat thickness (VFT) and anthropometric measurements associated with the development of NAFLD in patients mono-infected with HIV and on long-standing combination antiretroviral therapy (cART).Method: Eighty-eight (n = 88) HIV-positive male patients, average age 39.94 ± 9.91 years, and stable on cART, were included in this prospective study. VFT was measured using ultrasonography. Anthropometric measurements included body mass index (BMI), waist-to-hip ratio (W/H), waist-to-height ratio (WHtR), waist and hip circumference (WC, HC). Differences between variables were determined using the chi-square test. The receiver operating characteristic (ROC) curve and the Youden index were used to determine optimal cut-off values of VFT and hepatic steatosis. The area under the curve (AUC), 95% confidence intervals, sensitivity and specificity are reported for the complete sample. Significance was set at p 0.05.Results: Patients with steatosis had significantly higher values of BMI, HC, WC, W/H and WHtR. The VFT was higher in patients with steatosis (p 0.001). Specifically, VFT values above 31.98 mm and age 38.5 years correlated with steatosis in HIV-positive patients, namely sensitivity 89%, specificity 72%, AUC 0.84 (95% CI, 0.76–0.93, p 0.001), with the highest Youden index = 0.61. The sensitivity of the age determinant above this cut-off point was 84%, specificity 73% and AUC 0.83 (95% CI, 0.75–0.92, p 0.001), with the highest Youden index of 0.57.Conclusion: In the absence of more advanced radiographic and histological tools, simple anthropometric measurements and VFT could assist in the early identification of persons at risk of hepatic steatosis in low- and middle-income regions. | |
| Publisher | AOSIS | |
| Date | 2019-08-07 | |
| Identifier | 10.4102/sajhivmed.v20i1.968 | |
| Source | Southern African Journal of HIV Medicine; Vol 20, No 1 (2019); 6 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
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https://sajhivmed.org.za/index.php/hivmed/article/view/968/1561
https://sajhivmed.org.za/index.php/hivmed/article/view/968/1560
https://sajhivmed.org.za/index.php/hivmed/article/view/968/1562
https://sajhivmed.org.za/index.php/hivmed/article/view/968/1559
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/968/917
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