HIV-associated neurocognitive disorder in a KwaZulu-Natal HIV clinic: A prospective study
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | HIV-associated neurocognitive disorder in a KwaZulu-Natal HIV clinic: A prospective study | |
| Creator | Mogambery, Jade C. Dawood, Halima Wilson, Douglas Moodley, Anand | |
| Description | Introduction: HIV-associated neurocognitive disorder (HAND) is a consequence of HIV infection of the central nervous system. The prevalence ranges between 15% and 60% in different settings.Objectives: This prospective study determined the prevalence of HAND at a peri-urban HIV clinic in KwaZulu-Natal. Factors associated with HAND were examined, alternate neurocognitive tools were tested against the international HIV dementia scale (IHDS) score and an association between HAND and non-adherence to antiretroviral therapy (ART) was explored.Methods: Between May 2014 and May 2015, 146 ART-naïve outpatients were assessed for HAND. IHDS score ≤ 10 established a diagnosis of HAND. Functional capacity was assessed using Eastern Cooperative Oncology Group (ECOG) score. Chi-squared test was used to identify risk factors for HAND. The get-up-and-go test (GUGT) and Center for Epidemiological Studies Depression scale – revised (CESD-r) were tested against the IHDS. HIV viral load done six months after initiating ART was used as a surrogate marker for adherence to ART.Results: The prevalence of HAND was 53%. In total, 99.9% of patients with HAND had no functional impairment. Age 50 years old was associated with HAND (p = 0.003). There was no correlation between the GUGT, CESD-r and the IHDS score. HAND was not associated with non-adherence (p = 0.06).Conclusions: While the prevalence of HAND is high, it is not associated with functional impairment which suggests that asymptomatic neurocognitive impairment is prevalent. Age 50 years old is a risk factor for HAND. The GUGT and CESD-r are not useful diagnostic tools for HAND. The relationship between HAND and non-adherence should be further explored. | |
| Publisher | AOSIS | |
| Date | 2017-09-26 | |
| Identifier | 10.4102/sajhivmed.v18i1.732 | |
| Source | Southern African Journal of HIV Medicine; Vol 18, No 1 (2017); 5 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/732/1014
https://sajhivmed.org.za/index.php/hivmed/article/view/732/1013
https://sajhivmed.org.za/index.php/hivmed/article/view/732/1015
https://sajhivmed.org.za/index.php/hivmed/article/view/732/1008
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