Bacterial vaginosis, alterations in vaginal flora and HIV genital shedding among HIV-1-infected women in Mozambique
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Bacterial vaginosis, alterations in vaginal flora and HIV genital shedding among HIV-1-infected women in Mozambique | |
| Creator | Kirkcaldy, Robert D Mika, Jennifer Newman, Lori M Langa, Judite Tian, Linhui Jani, Ilesh Ballard, Ron Nelson, Lisa Folgosa, Elena | |
| Description |
Objectives. We investigated whether abnormal vaginal flora, including bacterial vaginosis (BV), are associated with detection of cervical HIV-1 RNA among HIV-infected women in Mozambique. Methods. We obtained clinical data and vaginal specimens from HIV-infected women registering for their first visit at one of two HIV care clinics in Mozambique. We compared women with detectable cervical HIV viral load (≥40 copies/ml) with women with undetectable cervical HIV. Results. We enrolled 106 women. Women with abnormal vaginal flora (intermediate Nugent scores, 4 - 6) were more likely to have detectable cervical HIV RNA then women with normal vaginal flora (adjusted odds ratio 7.2 (95% confidence interval 1.8 - 29.1), adjusted for CD4 count). Women with BV had a non-significantly higher likelihood of detectable cervical HIV than women with normal flora. Conclusions. Abnormal vaginal flora were significantly associated with cervical HIV expression. Further research is needed to confirm this relationship. |
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| Publisher | AOSIS | |
| Date | 2011-05-26 | |
| Identifier | 10.4102/sajhivmed.v12i2.193 | |
| Source | Southern African Journal of HIV Medicine; Vol 12, No 2 (2011); 22-24 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/193/326
https://sajhivmed.org.za/index.php/hivmed/article/view/193/325
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