Lipodystrophy syndrome in HIV-infected children on HAART
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Lipodystrophy syndrome in HIV-infected children on HAART | |
| Creator | Innes, Steve Levin, Leon Cotton, Mark | |
| Description | Lipodystrophy Syndrome (LD) is common in HIV-infected children, particularly in those taking Didanosine, Stavudine, or Zidovudine. Lipoatrophy in particular causes major stigmatization and interferes with adherence. In addition, LD may have significant long-term health consequences, particularly cardiovascular. Since the stigmatizing fat distribution changes of LD are largely permanent, the focus of management remains on early detection and arresting progression. Practical guidelines for surveillance and avoidance of LD in routine clinical practice are presented. Diagnosis of LD is described and therapeutic options are reviewed. The most important therapeutic intervention is to switch the most likely offending antiretroviral to a non-LD-inducing agent as soon as LD is recognised. Typically, where lipoatrophy or lipohypertrophy is diagnosed, the thymidine nucleoside reverse transcriptase inhibitor (NRTI) is switched to a non-thymidine agent such as Abacavir (or Tenofovir in adults). Where dyslipidaemia is predominant, a dietician review is helpful, and the clinician may consider switching to a protease inhibitor (PI)-sparing regimen or to Atazanavir. | |
| Publisher | AOSIS | |
| Date | 2009-12-14 | |
| Identifier | 10.4102/sajhivmed.v10i4.264 | |
| Source | Southern African Journal of HIV Medicine; Vol 10, No 4 (2009); 76 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/264/402
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/264/115
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/264/116
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/264/117
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/264/118
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/264/119
https://sajhivmed.org.za/index.php/hivmed/article/downloadSuppFile/264/120
|
|
ADVERTISEMENT
