Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group
Southern African Journal of HIV Medicine
| Field | Value | |
| Title | Unexpected low frequency of respiratory symptoms in an HIV-positive urban sub-Saharan population compared to an HIV-negative control group | |
| Creator | Kummerow, Maren Shaddock, Erica J. Klipstein-Grobusch, Kerstin Barth, Roos B. Grobbee, Diederick E. Venter, Francois D.F. Feldman, Charles Vos, Alinda | |
| Description | Background: Chronic respiratory illnesses and respiratory infections are common in HIV-positive populations. It seems reasonable that HIV-positive people experience more respiratory symptoms, such as coughing and breathlessness, than those who are HIV-negative.Objectives: This study aims to determine the frequency of respiratory symptoms in an urban African HIV-positive population.Method: A cross-sectional study was conducted in Johannesburg, South Africa, in 2016–2017. Four groups of participants were included: HIV-positive participants (1) not yet on antiretroviral therapy (ART), (2) on first-line ART, (3) on second-line ART and (4) age- and sex-matched HIV-negative controls. Data were collected on socio-demographics, respiratory risk factors and respiratory symptoms. A logistic regression analysis was performed to determine if respiratory symptoms differed between groups and to identify determinants associated with symptoms.Results: Overall, 547 participants were included, of whom 62% were women, with a median age of 37 years. Of these patients, 63% (347) were HIV-positive, 26% were ART-naïve, 24% were on first-line ART and 50% were on second-line ART. Cough and/or productive cough was reported by 27 (5%), wheezing by 9 (2%) and breathlessness by 118 (22%) of the participants. The frequency of these symptoms did not differ by HIV status after adjustment for age and sex. Breathlessness was associated with age, female sex, obesity, a history of respiratory infection and a history of airway hyper-reactivity.Conclusion: The frequency of respiratory symptoms was low in our study population except for breathlessness. HIV-positive participants, whether or not on ART, did not experience more symptoms than HIV-negative participants. | |
| Publisher | AOSIS | |
| Date | 2019-09-26 | |
| Identifier | 10.4102/sajhivmed.v20i1.1010 | |
| Source | Southern African Journal of HIV Medicine; Vol 20, No 1 (2019); 7 pages 2078-6751 1608-9693 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://sajhivmed.org.za/index.php/hivmed/article/view/1010/1625
https://sajhivmed.org.za/index.php/hivmed/article/view/1010/1624
https://sajhivmed.org.za/index.php/hivmed/article/view/1010/1626
https://sajhivmed.org.za/index.php/hivmed/article/view/1010/1623
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