Value of apparent diffusion coefficient (ADC) in evaluating response of carcinoma of the cervix treated with chemoradiotherapy
SA Journal of Radiology
| Field | Value | |
| Title | Value of apparent diffusion coefficient (ADC) in evaluating response of carcinoma of the cervix treated with chemoradiotherapy | |
| Creator | le Roux, A.J. Gebremariam, F.A. Harmse, W.S | |
| Description | Objective: To determine whether the apparent diffusion coefficient (ADC) value obtained by diffusion-weighted magnetic resonance imaging (DW-MRI) can be used as a reliable detector of response of carcinoma of the cervix treated with chemoradiotherapy, compared with conventional T2-weighted MRI.Design: A prospective cohort study was performed.Setting: Department of Oncology, Universitas-National Hospital Complex, Bloemfontein.Subjects: Seventeen women with advanced cervical cancer, FIGO staging IIB - IVB, were selected for chemoradiation.Outcome measures: Patients underwent pelvic MRI before therapy, 14 days after onset of therapy, and in the last week of treatment (5th/6th week). Axial and sagittal conventional T2 was followed by DW-MRI in the axial plane from which a tumour region of interest (ROI) was manually drawn to calculate ADC values using b-values of 500 and 1 000 s/mm2.Results: ADC values for cervical carcinoma increased after treatment with chemoradiation. The most significant observation was seen 14 days after treatment was started. The mean ADC value increased with 20% (b=500 s/mm2) and 24% (b=1 000 s/mm2) (statistically significant, p0.05) compared with a decrease in tumour size of only 8%, which was not statistically significant (p=0.075). Responders showed a larger change in ADC values than non-responders.Conclusion: The study showed considerable promise in the ability of ADC to identify early tumour response to therapy. DW-MRI is a non-invasive functional imaging technique that may in future change management in oncology by early identification of non-responders, hence avoiding unnecessary treatment. | |
| Publisher | AOSIS | |
| Date | 2013-03-05 | |
| Identifier | 10.4102/sajr.v17i1.203 | |
| Source | South African Journal of Radiology; Vol 17, No 1 (2013); 11-15 2078-6778 1027-202X | |
| Language | eng | |
| Relation |
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https://sajr.org.za/index.php/sajr/article/view/203/218
https://sajr.org.za/index.php/sajr/article/view/203/217
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https://sajr.org.za/index.php/sajr/article/downloadSuppFile/203/71
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