MRI diagnosis of Alexander disease

SA Journal of Radiology

Field Value
Title MRI diagnosis of Alexander disease
Creator Muralidharan, C G Tomar, R P S Aggarwal, R
Subject Radiology Macroencephaly, Leucoencephalopathy, Frontal preponderance, Periventricular rim, Cystic cavitation
Description Alexander disease (fibrinoid leucodystrophy; originally described by Alexander in 1949) is a rare, fatal, nonfamilial leucoencephalopathy caused by astrocyte dysfunction characterised by missense mutation in the genes coding for glial fibrillary acidic protein(GFAP). It typically presents with frontal preponderance of white matter abnormalities and macroencephaly. We report a case of leucoencephalopathy with macroencephaly that shows characteristic MRI features of Alexander disease.
Publisher AOSIS
Date 2012-09-10
Type info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion —
Format text/html application/pdf
Identifier 10.4102/sajr.v16i3.296
Source South African Journal of Radiology; Vol 16, No 3 (2012); 116-117 2078-6778 1027-202X
Language eng
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Coverage India
Rights Copyright (c) 2012 C G Muralidharan, R P S Tomar, R Aggarwal