Evaluation of plant-produced Clostridium perfringens type D epsilon toxoid in a vaccine against enterotoxaemia in sheep
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Evaluation of plant-produced Clostridium perfringens type D epsilon toxoid in a vaccine against enterotoxaemia in sheep | |
| Creator | Mokoena, Tinyiko Chakauya, Ereck Crampton, Michael Weyers, Boet Tselanyane, Malefa Tsekoa, Tsepo Chikwamba, Rachel | |
| Description | Enterotoxaemia (pulpy kidney) is a common bacterial disease of sheep caused by Clostridium perfringens type D epsilon toxin. It has mortality rates of up to 30% in non-vaccinated animals. Current vaccines from whole cell cultures are expensive to manufacture and can induce local inflammatory responses in sheep. They usually have reduced immunogenicity because of the difficulty of standardising the inactivation step in vaccine manufacturing. In the current study, we evaluated the safety and potency of a recombinant plant-made epsilon toxoid protein (r-Etox) as an affordable and safer alternative vaccine for developing countries. Results of injection site reactions, rectal temperature and toxin neutralisation test in single and prime– boost inoculations of mice, guinea pigs and sheep suggest that the product is not toxic to animals and could protect sheep against enterotoxaemia. | |
| Publisher | AOSIS | |
| Date | 2017-04-25 | |
| Identifier | 10.4102/ojvr.v84i1.1271 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 84, No 1 (2017); 7 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/1271/1636
https://ojvr.org/index.php/ojvr/article/view/1271/1635
https://ojvr.org/index.php/ojvr/article/view/1271/1637
https://ojvr.org/index.php/ojvr/article/view/1271/1632
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