Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Comparison of pathogenic domains of rabies and African rabies-related lyssaviruses and pathogenicity observed in mice | |
| Creator | Kgaladi, Joe Nel, Louis H. Markotter, Wanda | |
| Description | Several lyssavirus species occur in Africa (Rabies virus, Lagos bat virus, Mokola virus, Duvenhage virus, Shimoni bat virus and Ikoma lyssavirus), displaying a high sequence diversity between isolates belonging to the same species. There is limited information about comparative pathogenesis of these African lyssaviruses and this precludes authoritative opinion on the potential public and veterinary health impact. In this study, an analysis of representative African lyssaviruses attempted to correlate viral genomic sequence similarities and differences with the corresponding pathogenic profiles observed in mice. The study demonstrated that the virus isolates evaluated could be lethal to mice when introduced intramuscularly and that different isolates of the same lyssavirus species differ in their virulence. Using real-time polymerase chain reaction (PCR), viral RNA was detected in brain tissue, but no viral RNA was detected in the salivary glands or blood of mice that succumbed to infection. Comparison of known pathogenic domains indicated that pathogenicity is likely to be dependent on multiple domains. Cumulatively, our results re-emphasised the realisation that the pathogenicity of a lyssavirus species cannot be deduced based on studies of only a single isolate of the species or a single pathogenic domain. | |
| Publisher | AOSIS | |
| Date | 2013-03-08 | |
| Identifier | 10.4102/ojvr.v80i1.511 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 80, No 1 (2013); 13 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/511/805
https://ojvr.org/index.php/ojvr/article/view/511/806
https://ojvr.org/index.php/ojvr/article/view/511/807
https://ojvr.org/index.php/ojvr/article/view/511/804
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