Genetic characterisation of African swine fever virus from 2017 outbreaks in Zambia: Identification of p72 genotype II variants in domestic pigs
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Genetic characterisation of African swine fever virus from 2017 outbreaks in Zambia: Identification of p72 genotype II variants in domestic pigs | |
| Creator | Simulundu, Edgar Sinkala, Yona Chambaro, Herman M. Chinyemba, Andrew Banda, Frank Mooya, Lynnfield E. Ndebe, Joseph Chitanga, Simbarashe Makungu, Chitwambi Munthali, Gift Fandamu, Paul Takada, Ayato Mweene, Aaron S. | |
| Description | African swine fever (ASF) is a contagious haemorrhagic disease associated with causing heavy economic losses to the swine industry in many African countries. In 2017, Zambia experienced ASF outbreaks in Mbala District (Northern province) and for the first time in Isoka and Chinsali districts (Muchinga province). Meanwhile, another outbreak was observed in Chipata District (Eastern province). Genetic analysis of part of the B646L gene, E183L gene, CP204L gene and the central variable region of the B602L gene of ASF virus (ASFV) associated with the outbreaks in Mbala and Chipata districts was conducted. The results revealed that the ASFV detected in Mbala District was highly similar to that of the Georgia 2007/1 isolate across all the genome regions analysed. In contrast, while showing close relationship with the Georgia 2007/1 virus in the B646L gene, the ASFV detected in Chipata District showed remarkable genetic variation in the rest of the genes analysed. These results suggest that the Georgia 2007/1-like virus could be more diverse than what was previously thought, underscoring the need of continued surveillance and monitoring of ASFVs within the south-eastern African region to better understand their epidemiology and the relationships between outbreaks and their possible origin. | |
| Publisher | AOSIS | |
| Date | 2018-06-26 | |
| Identifier | 10.4102/ojvr.v85i1.1562 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 85, No 1 (2018); 5 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/1562/1743
https://ojvr.org/index.php/ojvr/article/view/1562/1742
https://ojvr.org/index.php/ojvr/article/view/1562/1744
https://ojvr.org/index.php/ojvr/article/view/1562/1741
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