On the origin and diversity of Newcastle disease virus in Tanzania
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | On the origin and diversity of Newcastle disease virus in Tanzania | |
| Creator | Yongolo, Mmeta G. Christensen, Henrik Handberg, Kurt Minga, Uswege Olsen, John E. | |
| Description | Free-range rural chickens (FRCs) dominate the poultry industry in developing countries and chickens are exposed to multi-host infections, including Newcastle disease virus (NDV). The knowledge about the characteristics of NDV from FRCs is limited. This study investigated the persistence, spread and risks of NDV from FRCs. NDV isolates (n = 21) from unvaccinated FRCs in Tanzania were characterised by conventional intracerebral pathogenicity index (ICPI) and sequence analysis of a partial region of the deduced fusion protein encompassing the cleavage site. Results showed that five isolates were screened as lentogenic, nine as mesogenic and six as velogenic. Phylogenetic analysis of the 21 isolates compared to reference sequences revealed three, four, nine and five isolates in genotypes 1, 2, 3c and 4a, respectively. Genotype 3c also included published sequences of Tanzanian isolates obtained from exotic birds and chicken isolates from Uganda. The analysis showed that NDV were persistently present among chicken populations and possibly spread through live chicken markets or migration of wild birds. Differences in amino acid sequences detected around the cleavage site separated the isolates in six types. However, cleavage site pattern could not fully differentiate mesogenic isolates from velogenic isolates. | |
| Publisher | AOSIS | |
| Date | 2011-09-30 | |
| Identifier | 10.4102/ojvr.v78i1.312 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 78, No 1 (2011); 8 pages 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/312/354
https://ojvr.org/index.php/ojvr/article/view/312/361
https://ojvr.org/index.php/ojvr/article/view/312/355
https://ojvr.org/index.php/ojvr/article/view/312/322
https://ojvr.org/index.php/ojvr/article/downloadSuppFile/312/244
https://ojvr.org/index.php/ojvr/article/downloadSuppFile/312/245
https://ojvr.org/index.php/ojvr/article/downloadSuppFile/312/246
https://ojvr.org/index.php/ojvr/article/downloadSuppFile/312/247
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