Human cystic echinococcosis in South Africa
Onderstepoort Journal of Veterinary Research
| Field | Value | |
| Title | Human cystic echinococcosis in South Africa | |
| Creator | Mogoye, Benjamin Menezes, Colin N. Grobusch, Martin P. Wahlers, Kerstin Frean, John | |
| Description | Cystic echinococcosis (CE) is caused by the tapeworm, Echinococcus granulosus. The tapeworms resides in the small intestines of canids and the lifecycle involves both intermediate and definitive hosts. Humans are accidental intermediate hosts. Cystic echinococcosis is an economically important infection constituting a threat to public health, and is considered an emerging disease around the world. There are at least 10 Echinococcus strain types (G1 – G10), each exhibiting diversity of morphology, development and host range. The epidemiology of CE is poorly understood in South Africa. A retrospective data analysis of the National Health Laboratory Service (NHLS) laboratory information system on echinococcosis serology, microscopy and histopathology results in eight provinces (excluding KwaZula-Natal) showed an overall positivity rate in submitted diagnostic samples of 17.0% (1056/6211), with the Eastern Cape (30.4%), North West (19.0%) and Northern Cape (18.0%) provinces showing highest rates. The data showed considerable variability between provinces. The review also showed that most proven cases were negative on serology, implying that the actual number of patients could be underestimated. To our knowledge, no data exist about the prevalent strains of E. granulosus and this prospective study will attempt to fill that gap. The aim is to genotype strains causing the disease in South Africa. Two different polymerase chain reaction (PCR) methods will be used to respectively target the 12S rRNA and nad 1 genes. To date, three samples have been genotyped as G1, G5 and G6; suggesting diversity of strains prevalent in the country, but more data is needed for a clearer picture. | |
| Publisher | AOSIS | |
| Date | 2012-06-20 | |
| Identifier | 10.4102/ojvr.v79i2.469 | |
| Source | Onderstepoort Journal of Veterinary Research; Vol 79, No 2 (2012); 1 page 2219-0635 0030-2465 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ojvr.org/index.php/ojvr/article/view/469/600
https://ojvr.org/index.php/ojvr/article/view/469/655
https://ojvr.org/index.php/ojvr/article/view/469/657
https://ojvr.org/index.php/ojvr/article/view/469/537
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