Record Details

Antiretroviral therapy-induced Leber’s hereditary optic neuropathy

Southern African Journal of HIV Medicine


 
 
Field Value
 
Title Antiretroviral therapy-induced Leber’s hereditary optic neuropathy
 
Creator Moodley, Anand; Department of Neurology, Grey’s Hospital, Pietermaritzburg and University of KwaZulu-Natal, Durban, South Africa Bhola, Sudika; Department of Neurology, Grey’s Hospital, Pietermaritzburg and University of KwaZulu-Natal, Durban, South Africa Omar, Fierdoz; Chemical Pathology Laboratory, Groote Schuur Hospital; National Health Laboratory Service and University of Cape Town, South Africa Mogambery, Jade; Department of Medicine, Grey’s Hospital, Pietermaritzburg, South Africa
 
Subject Infectious disease; Neurology; Neuro-ophthalmology; Ophthalmology Leber's hereditary optic neuropathy; LHON; Nucleoside reverse transcriptase inhibitor; antiretrovirals; mitochondrial disease Neuro-ophthalmology
Description Optic neuropathy in HIV-infected patients results from the HIV infection itself, post-infectious auto-immune disease, opportunistic infections and drugs. Nucleoside reverse transcriptase inhibitors (NRTIs) such as zidovudine and stavudine have known mitochondrial toxicity and can cause mitochondrial myopathies, neuropathies, hyperlactataemia, and can induce mitochondrial genetic disorders. Individuals with the mutation for Leber’s hereditary optic neuropathy (LHON), a mitochondrial disorder, are usually asymptomatic but develop visual loss when exposed to external triggers such as smoking. We report on two HIV-infected patients with LHON mutations (m.14484T>C and m.11778G>A) who developed profound visual loss with antiretroviral therapy. We postulate that the phenotypic expression of LHON in these genetically predisposed individuals was triggered by NRTI drugs lamivudine and tenofovir when used in combination, despite their relatively weak mitochondrial toxic effects. 
 
Publisher AOSIS Publishing
 
Date 2014-05-23
 
Type
Format application/pdf
Identifier 10.4102/hivmed.v15i2.24
 
Source Southern African Journal of HIV Medicine; Vol 15, No 2 (2014); 69-71
 
Language en
 
Relation http://www.sajhivmed.org.za/index.php/hivmed/article/download/24/37 http://www.sajhivmed.org.za/index.php/hivmed/article/download/24/38 http://www.sajhivmed.org.za/index.php/hivmed/article/download/24/39
 
Coverage South Africa 2012 to 2014
Rights Copyright information Ownership of copyright in terms of the Work remains with the authors.The authors retain the non-exclusive right to do anything they wish with the Work, provided attribution is given to the place and detail of original publication, as set out in the official citation of the Work published in the journal. The retained right specifically includes the right to post the Work on the authors’ or their institutions’ websites or institutional repository.Publication and user license The authors grant the title owner and the publisher an irrevocable license and first right and perpetual subsequent right to (a) publish, reproduce, distribute, display and store the Work in  any form/medium, (b) to translate the Work into other languages, create adaptations, summaries or extracts of the Work or other derivative works based on the Work and exercise all of the rights set forth in (a) above in such translations, adaptations, summaries, extracts and derivative works, (c) to license others to do any or all of the above, and (d) to register the Digital Object Identifier (DOI) for the Definitive Work.The authors acknowledge and accept the user licence under which the Work will  be published as set out in http://creativecommons.org/licenses/by/2.5/za/legalcode (Creative Commons Attribution License South Africa)The undersigned warrant that they have the authority to license these publication rights and that no portion of the copyright to the Work has been assigned or licensed previously to any other party.Disclaimer: The publisher, editors and title owner accept no responsibility for any statement made or opinion expressed by any other person in this Work. Consequently, they will not be liable for any loss or damage sustained by any reader as a result of his or her action upon any statement or opinion in this Work. In cases where a manuscript is NOT accepted for publication by the editorial board, the portions of this agreement regarding the publishing licensing shall be null and void and the authors will be free to submit this manuscript to any other publication for first publication.Our copyright policies are author-friendly and protect the rights of our authors and publishing partners.