Prevalence, intensity and complications of Microsporidium spores amongst HIV-positive hospital patients in Ilorin, Nigeria
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Prevalence, intensity and complications of Microsporidium spores amongst HIV-positive hospital patients in Ilorin, Nigeria | |
| Creator | Nyamngee, Amase Edungbola, Luke D. Agbede, Olajide O. Salami, Alakija K. Nwabuisi, Charles Akanbi II, Aliu A. Ibrahim, Olatunde O.K. Tilahun, Muchae Moser, Douglas B. | |
| Description | Background: Microsporidiasis, which is of great concern for immunocompromised patients, is poorly studied in developing countries.Objectives: A study was carried out amongst HIV-positive hospital patients and HIV-negative hospital controls in Ilorin, Nigeria, between January 2009 and July 2010 to determine the prevalence and intensity of Microsporidium spores and the complications associated with their presence.Method: Stool samples from 750 HIV-positive patients and 375 HIV-negative patients were studied using the Chromotrope-2R staining technique. Determination of CD4+ count was performed on the Partec Cyflow SL-3 CD4/8 instrument. Intensity of spores was determined by counting the total number of the spores in a 10 μl stained smear of stool. Images were captured with Phenix Microimage Analysis Software and data obtained were analysed using the Statistical Package for the Social Sciences.Results: The prevalence of Microsporidium isolates amongst the HIV-positive hospital patients was significantly higher (42.4%) than amongst the HIV-negative controls (19.2%)(p 0.05). The intensity of microsporidial spores amongst HIV-positive hospital patients was also significantly higher than amongst the controls (p 0.05). However, the difference in the intensity of spores amongst HIV-positive patients who were on antiretroviral therapy(n = 411) and those who were not (n = 339) was not significant (p = 0.236). Microsporidiasis in HIV infection infection was common amongst patients with with low CD4+ counts, diarrhoea, body rashes and cough.Conclusion: Both the prevalence and intensity of Microsporidiasis are high amongst HIV-positive hospital patients; campaigns to promote awareness, prevention and control are required. Laboratory testing for microsporidia in HIV patients should be performed routinely so as to identify the organism for prompt medical attention. | |
| Publisher | AOSIS | |
| Date | 2013-11-26 | |
| Identifier | 10.4102/ajlm.v2i1.66 | |
| Source | African Journal of Laboratory Medicine; Vol 2, No 1 (2013); 6 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/66/135
https://ajlmonline.org/index.php/ajlm/article/view/66/136
https://ajlmonline.org/index.php/ajlm/article/view/66/137
https://ajlmonline.org/index.php/ajlm/article/view/66/134
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