Record Details

Systemic inflammatory response syndrome and multiple-organ damage / dysfunction in complicated canine babesiosis

Journal of the South African Veterinary Association

Field Value
Title Systemic inflammatory response syndrome and multiple-organ damage / dysfunction in complicated canine babesiosis
Creator Welzl, C. Leisewitz, A.L. Jacobson, L.S. Vaughan-Scott, T. Myburgh, E.
Subject — Babesia Canis; Babesiosis; Canine; MODS; Multiple-Organ Dysfunction Syndrome; Multiple-Organ Failure; SIRS; Systemic Inflammatory Response Syndrome
Description This study was designed to document the systemic inflammatory response syndrome (SIRS) and multiple-organ dysfunction syndrome (MODS) in dogs with complicated babesiosis, and to assess their impact on outcome. Ninety-one cases were evaluated retro-spectively for SIRS and 56 for MODS. The liver, kidneys, lungs, central nervous system and musculature were assessed. Eighty-seven percent of cases were SIRS-positive. Fifty-two percent of the cases assessed for organ damage had single-organ damage and 48 % had MODS. Outcome was not significantly affected by either SIRS or MODS, but involvement of specific organs had a profound effect. Central nervous system involvement resulted in a 57 times greater chance of death and renal involvement in a 5-fold increased risk compared to all other complications. Lung involvement could not be statistically evaluated owing to co-linearity with other organs, but was associated with high mortality. Liver and muscle damage were common, but did not significantly affect outcome. There are manysimilarities between the observations in this study and previous human and animal studies in related fields, lending additional support to the body of evidence for shared underlying pathophysiological mechanisms in systemic inflammatory states.
Publisher AOSIS Publishing
Date 2001-07-09
Type — —
Format application/pdf
Identifier 10.4102/jsava.v72i3.640
Source Journal of the South African Veterinary Association; Vol 72, No 3 (2001); 158-162
Language en
Coverage — — —
Rights Copyright information Ownership of copyright in terms of the Work remains with the authors. The authors retain the non-exclusive right to do anything they wish with the Work, provided attribution is given to the place and detail of original publication, as set out in the official citation of the Work published in the journal. The retained right specifically includes the right to post the Work on the authors’ or their institutions’ websites or institutional repository. Disclaimer: The publisher, editors and title owner accept no responsibility for any statement made or opinion expressed by any other person in this Work. Consequently, they will not be liable for any loss or damage sustained by any reader as a result of his or her action upon any statement or opinion in this Work. In cases where a manuscript is NOT accepted for publication by the editorial board, the portions of this agreement regarding the publishing licensing shall be null and void and the authors will be free to submit this manuscript to any other publication for first publication. Our copyright policies are author-friendly and protect the rights of our authors and publishing partners.