Record Details

The pathology of acute Nolletia gariepina poisoning of cattle

Journal of the South African Veterinary Association


 
 
Field Value
 
Title The pathology of acute Nolletia gariepina poisoning of cattle
 
Creator Du Plessis, E. C.; VETPATH, A Division of Idexx Laboratories, PO Box 12731, Onderstepoort, 0110 South Africa.

Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa. Prozesky, L; Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa. Botha, C. J.; Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort, 0110 South Africa.
 
Subject — —
Description Toxicity in cattle by the shrub Nolletia gariepina was induced experimentally by intraruminal administration of 3 g/kg dried, milled plant material as a single dose. The animals had to be starved for 24 hours before dosing, as dosing on a full rumen did not induce any signs of toxicity during 5 days of observation and clinical pathology monitoring. Clinical signs were not specific and varied according to the duration (acute versus subacute) of the toxicological process. Clinical pathological parameters indicated renal and to a lesser extent hepatic damage, with raised serum concentrations of urea, creatinine, aspartate aminotransferase (AST) and gamma glutamyl transferase (GGT). Increased urinary sodium and potassium concentration and GGT activity, as well as proteinuria, were evident. Histological and electron microscopic examinations revealed acute renal tubular epithelial cell degeneration and necrosis, especially of the proximal convoluted tubules. Mild hepatocellular degeneration was also noticeable.
 
Publisher AOSIS Publishing
 
Contributor
Date 2011-04-13
 
Type — —
Format application/pdf
Identifier 10.4102/jsava.v82i3.52
 
Source Journal of the South African Veterinary Association; Vol 82, No 3 (2011); 144-149
 
Language en
 
Coverage — — —
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