Thoracic epidural for post-thoracic epidural for post-thoracotomy pain: a comparison of three concentrations of sufentanil in bupivacaine
Southern African Journal of Anaesthesia and Analgesia
| Field | Value | |
| Title | Thoracic epidural for post-thoracic epidural for post-thoracotomy pain: a comparison of three concentrations of sufentanil in bupivacaine | |
| Creator | Singh, Vinita Kaushal, Dinesh Yadav, Naveen Gupta, Rajni Kumar, Suresh Chandra, Girish Bhatia, Virendra K | |
| Description | Background: Aim of this prospective, double blind, randomized trial was to compare the analgesic and adverse effects of three concentrations, of thoracic epidural sufentanil with bupivacaine in patients undergoing thoracotomy. Methods: We studied 60 patients who were randomized to receive a 10ml bolus dose of sufentanil 1 ïg/ml, 2 ïg/ml and 3 ïg/ml in bupivacaine 0.125% via thoracic epidural. Postoperatively, pain at rest, on coughing and with ambulation was assessed using a visual analogue scale (VAS) and observer verbal ranking score (OVRS) at 2, 6, 12 24 hours. At the same time adverse effects were assessed. Results: There was no significant difference in the baseline characteristics between the three groups. The number of patients with episodes of unsatisfactory pain i.e. VAS scores 40 and OVRS 2, at each of the four assessment postoperatively was significantly higher with sufentanil 1 ïg/ml than with sufentanil 2 ïg/ml or 3 ïg/ml (p0.05). In 3 ïg/ml sufentanil group, 4 patients (20%) had sedation score 3 compared with 1 (5%) and 0 patients in 2 ïg/ml and 1 ïg/ml sufentanil groups, respectively (p0.05). In addition 30% patients experienced pruritus in 3 ïg/ml sufentanil group compared with 10% and 5%, respectively in 2 ïg/ml and 1 ïg/ml sufentanil groups. 30%, 20% 5% patients, respectively in sufentanil 3 ïg/ml, 2 ïg/ml 1 ïg/ml groups had emetics symptoms (p0.05). Conclusions: We concluded that thoracic epidural bolus of 10ml sufentanil 2 ïg/ml with bupivacaine 0.125% provides the optimal balance between pain relief and side effects following thoracotomy. | |
| Publisher | AOSIS | |
| Date | 2009-04-01 | |
| Identifier | 10.1080/22201173.2009.10872601 | |
| Source | Southern African Journal of Anaesthesia and Analgesia; Vol 15, No 2 (2009); 16-21 2220-1173 2220-1181 | |
| Language | eng | |
| Relation |
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https://sajaa.co.za/index.php/sajaa/article/view/348/342
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