Erythrocyte glucose-6-phosphate dehydrogenase deficiency-induced anaemia in children in Jos, North-Central Nigeria
African Journal of Laboratory Medicine
| Field | Value | |
| Title | Erythrocyte glucose-6-phosphate dehydrogenase deficiency-induced anaemia in children in Jos, North-Central Nigeria | |
| Creator | Niandat, Justine D. Okoli, Caroline A. | |
| Description | Background: Glucose-6-phosphate dehydrogenase deficiency (G6PDD), a common inherited enzyme defect, associated with severe neonatal anaemia and hyperbilirubinaemia, can result in permanent neurologic damage or death. Prevalence of G6PDD-induced anaemia in vulnerable groups, like children, is not known in our setting.Objective: This study was aimed at determining the prevalence of erythrocyte G6PDD-induced anaemia among children aged 0–5 years old seen at Jos University Teaching Hospital, North-Central Nigeria.Methods: This was a hospital-based cross-sectional study conducted from February to June 2023. Glucose-6-phosphate dehydrogenase and haemoglobin levels were analysed colourimetrically. Data were analysed; p 0.05 was considered significant.Results: Out of 100 children aged 0–5 years (54 male, 46 female), 40 (40%) were G6PD deficient. Nineteen (35.2%) of the G6PD-deficient children were male and 21 (45.7%) were female. Fifty-one (51%) children were anaemic, 23 (57.5%) were G6PDD-induced; 85 (85%) of the parents had no knowledge of G6PD and its deficiency.Conclusion: This study showed a high prevalence of G6PDD-induced anaemia among children in Jos. This suggests that there may be a need for early routine G6PD screening in children for early detection and proper intervention in those with the deficiency.What this study adds: This study has objectively established high prevalence of anaemia, G6PDD and G6PDD-induced anaemia in children aged 0–5 years in Jos, Nigeria, highlighting the importance of G6PD screening in children. | |
| Publisher | AOSIS | |
| Date | 2025-10-14 | |
| Identifier | 10.4102/ajlm.v14i1.2733 | |
| Source | African Journal of Laboratory Medicine; Vol 14, No 1 (2025); 6 pages 2225-2010 2225-2002 | |
| Language | eng | |
| Relation |
The following web links (URLs) may trigger a file download or direct you to an alternative webpage to gain access to a publication file format of the published article:
https://ajlmonline.org/index.php/ajlm/article/view/2733/3280
https://ajlmonline.org/index.php/ajlm/article/view/2733/3281
https://ajlmonline.org/index.php/ajlm/article/view/2733/3282
https://ajlmonline.org/index.php/ajlm/article/view/2733/3283
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